Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-8-12
pubmed:abstractText
This paper presents a likelihood approach to population samples of microsatellite alleles. A Markov chain recursion method previously published by GRIFFITHS and TAVARE is applied to estimate the likelihood function under different models of microsatellite evolution. The method presented can be applied to estimate a fundamental population genetics parameter theta as well as parameters of the mutational model. The new likelihood estimator provides a better estimator of theta in terms of the mean square error than previous approaches. Furthermore, it is demonstrated how the method may easily be applied to test models of microsatellite evolution. In particular it is shown how to compare a one-step model of microsatellite evolution to a multi-step model by a likelihood ratio test.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9178018, http://linkedlifedata.com/resource/pubmed/commentcorrection/9178018-1132689, http://linkedlifedata.com/resource/pubmed/commentcorrection/9178018-1220043, http://linkedlifedata.com/resource/pubmed/commentcorrection/9178018-1675432, http://linkedlifedata.com/resource/pubmed/commentcorrection/9178018-1765387, http://linkedlifedata.com/resource/pubmed/commentcorrection/9178018-3744026, http://linkedlifedata.com/resource/pubmed/commentcorrection/9178018-4777279, http://linkedlifedata.com/resource/pubmed/commentcorrection/9178018-7153670, http://linkedlifedata.com/resource/pubmed/commentcorrection/9178018-7510853, http://linkedlifedata.com/resource/pubmed/commentcorrection/9178018-7657992, http://linkedlifedata.com/resource/pubmed/commentcorrection/9178018-7705647, http://linkedlifedata.com/resource/pubmed/commentcorrection/9178018-8159720, http://linkedlifedata.com/resource/pubmed/commentcorrection/9178018-8349120
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0016-6731
pubmed:author
pubmed:issnType
Print
pubmed:volume
146
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
711-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
A likelihood approach to populations samples of microsatellite alleles.
pubmed:affiliation
Department of Integrative Biology, University of California, Berkeley 94720-3140, USA. rasmus@mws4.biol.berkeley.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't