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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1997-8-18
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pubmed:abstractText |
The effect of the water soluble fraction of the ethanol extract of Nyctanthes arbor-tristis (NAT) on tumor necrosis factor-alpha (TNF-alpha) level in plasma of arthritic and soluble protein A (SpA)-treated Balb/c mice has been studied. Oral administration of this fraction in arthritic mice showed a consistent depletion of TNF-alpha from the host plasma. A similar depletion of TNF-alpha in the plasma of SpA-treated mice has been observed. The extract also reduces plasma interferon-gamma level but the plasma IgM and IgG levels are not affected. The implications of these observations are discussed in the light of management of TNF-alpha in clinical disorders.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0378-8741
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
153-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9174977-Administration, Oral,
pubmed-meshheading:9174977-Animals,
pubmed-meshheading:9174977-Arthritis, Experimental,
pubmed-meshheading:9174977-Blood Proteins,
pubmed-meshheading:9174977-Disease Models, Animal,
pubmed-meshheading:9174977-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:9174977-Ethanol,
pubmed-meshheading:9174977-Immunoblotting,
pubmed-meshheading:9174977-Immunoglobulin G,
pubmed-meshheading:9174977-Immunoglobulin M,
pubmed-meshheading:9174977-Interferon-gamma,
pubmed-meshheading:9174977-Male,
pubmed-meshheading:9174977-Mice,
pubmed-meshheading:9174977-Mice, Inbred BALB C,
pubmed-meshheading:9174977-Plant Extracts,
pubmed-meshheading:9174977-Plants, Medicinal,
pubmed-meshheading:9174977-Staphylococcal Protein A,
pubmed-meshheading:9174977-Tumor Necrosis Factor-alpha
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pubmed:year |
1997
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pubmed:articleTitle |
Depletion of tumor necrosis factor-alpha in mice by Nyctanthes arbor-tristis.
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pubmed:affiliation |
Immunobiology Laboratory, Industrial Taxicology Research Centre, Lucknow, India.
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pubmed:publicationType |
Journal Article
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