|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0039194,
umls-concept:C0040300,
umls-concept:C0230445,
umls-concept:C0330390,
umls-concept:C0439097,
umls-concept:C0439662,
umls-concept:C0475264,
umls-concept:C1547348,
umls-concept:C1552644,
umls-concept:C1705241,
umls-concept:C1744526,
umls-concept:C1823153,
umls-concept:C2003941,
umls-concept:C2349976
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1997-6-19
|
|
pubmed:abstractText |
The nature of the host's T-lymphocyte population within the intestinal villi following Cryptosporidium parvum infection was characterized with a bovine model of cryptosporidiosis. In naive animals, infection with C. parvum resulted in substantial increases in the numbers of alpha/beta T cells, both CD4+ (150%) and CD8+ (60%), and of gamma/delta T cells (70%) present within the intestinal villi of the infected ileum. In immune animals, the host T-lymphocyte response to a challenge infection with C. parvum was restricted to alpha/beta T cells. The number of CD4+ T cells within the Peyer's patch of the ileum increased dramatically; however, there was little change in the number or localization of CD4+ T cells within the intestinal villi. In contrast, the number of CD8+ T cells within the intestinal villi increased following a challenge infection. In addition, the CD8+ T cells were found to be intimately associated with the epithelial cells of the intestinal villi. The precise correlation between the accumulation of CD8+ T cells and the normal site of parasite development suggests an important role for CD8+ T cells in the immune animal.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-1452711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-1493930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-1587597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-1639500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-1677668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-1708557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-1818204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-1997443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-2021067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-2108043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-2365460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-2524098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-2671973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-3540573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-3585626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-6607888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-6843609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-7747401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-7818640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-7905464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-7907581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-7910592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-7970868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-8103040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-8116805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-8598471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-8613403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-8643541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-8698384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-8698479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-8721044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-8912874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9169784-8975910
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0019-9567
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
65
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2428-33
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:9169784-Animals,
pubmed-meshheading:9169784-Cattle,
pubmed-meshheading:9169784-Cryptosporidiosis,
pubmed-meshheading:9169784-Cryptosporidium parvum,
pubmed-meshheading:9169784-Ileum,
pubmed-meshheading:9169784-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:9169784-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:9169784-T-Lymphocyte Subsets
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
Localization of alpha/beta and gamma/delta T lymphocytes in Cryptosporidium parvum-infected tissues in naive and immune calves.
|
|
pubmed:affiliation |
Department of Veterinary PathoBiology, University of Minnesota, St. Paul 55108, USA. abrah025@gold.tc.umn.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|
