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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1997-6-12
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pubmed:databankReference |
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pubmed:abstractText |
We used positional cloning to identify the circadian Clock gene in mice. Clock is a large transcription unit with 24 exons spanning approximately 100,000 bp of DNA from which transcript classes of 7.5 and approximately 10 kb arise. Clock encodes a novel member of the bHLH-PAS family of transcription factors. In the Clock mutant allele, an A-->T nucleotide transversion in a splice donor site causes exon skipping and deletion of 51 amino acids in the CLOCK protein. Clock is a unique gene with known circadian function and with features predicting DNA binding, protein dimerization, and activation domains. CLOCK represents the second example of a PAS domain-containing clock protein (besides Drosophila PERIOD), which suggests that this motif may define an evolutionarily conserved feature of the circadian clock mechanism.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CLOCK Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CLOCK protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Clock protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0092-8674
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pubmed:author |
pubmed-author:AntochM PMP,
pubmed-author:KingD PDP,
pubmed-author:KornhauserJ MJM,
pubmed-author:LowreyP LPL,
pubmed-author:SangoramA MAM,
pubmed-author:SteevesT DTD,
pubmed-author:TakahashiJ SJS,
pubmed-author:TanakaMM,
pubmed-author:TurekF WFW,
pubmed-author:VitaternaM HMH,
pubmed-author:WilsbacherL DLD,
pubmed-author:ZhaiSS
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
641-53
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9160755-Amino Acid Sequence,
pubmed-meshheading:9160755-Animals,
pubmed-meshheading:9160755-Base Sequence,
pubmed-meshheading:9160755-CLOCK Proteins,
pubmed-meshheading:9160755-Chick Embryo,
pubmed-meshheading:9160755-Chromosome Mapping,
pubmed-meshheading:9160755-Circadian Rhythm,
pubmed-meshheading:9160755-Cloning, Molecular,
pubmed-meshheading:9160755-Conserved Sequence,
pubmed-meshheading:9160755-DNA, Complementary,
pubmed-meshheading:9160755-DNA Primers,
pubmed-meshheading:9160755-Dogs,
pubmed-meshheading:9160755-Drosophila,
pubmed-meshheading:9160755-Evolution, Molecular,
pubmed-meshheading:9160755-Humans,
pubmed-meshheading:9160755-Mice,
pubmed-meshheading:9160755-Molecular Sequence Data,
pubmed-meshheading:9160755-Mutation,
pubmed-meshheading:9160755-RNA, Messenger,
pubmed-meshheading:9160755-Sequence Homology, Amino Acid,
pubmed-meshheading:9160755-Trans-Activators
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pubmed:year |
1997
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pubmed:articleTitle |
Positional cloning of the mouse circadian clock gene.
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pubmed:affiliation |
National Science Foundation Center for Biological Timing, Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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