positional cloning

Source:http://linkedlifedata.com/resource/umls/id/C1656250

CSP: indirect exploration of a genetic disease by learning the location of the responsible gene, isolating and cloning its DNA, and translating the DNA to determine the protein product; by comparing this product with the product of the normal allele, one can also analyze the nature of the normal protein altered by the mutation; called also reverse genetics; do not confuse this term with EXPRESSION CLONING or MOLECULAR CLONING.

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