Linked Life Data

9118233

Source:http://linkedlifedata.com/resource/pubmed/id/9118233

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1997-4-23
pubmed:abstractText
When rat bone marrow macrophages were incubated with acetyl lignin (EP3) in the presence of a 10% solution of fetal bovine serum, the macrophages secreted tumor necrosis factor (TNF-alpha) in a dose-dependent manner. This was followed by macrophage multinucleation. EP3 was found to have a significant effect on TNF-alpha secretion at a minimum dose of 5 micrograms/ml and produced no significant further increase at levels above 50 micrograms/ml, while multinucleation was most active at 10 micrograms/ml. However, multinucleation did not occur at higher concentrations of EP3 (50 micrograms/ml and 100 micrograms/ml). Secretion of TNF-alpha was significantly reduced in the absence of fetal bovine serum, whereas multinucleation was very active, starting after 6 h of incubation. At concentrations of 100 micrograms/ml, sulfonyl lignin (LS) and dextran sulfate (DS) only induced low levels of TNF-alpha secretion from macrophages, but induced active multinucleation. The multinucleation induced by addition of LS or DS was inhibited by further addition of EP3. Thus, macrophage multinucleation was most active when a low level of TNF-alpha was secreted from the macrophages.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0386-7196
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
277-82
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Polyanion induced preferential multinucleation in macrophages at a low level of TNF-alpha secretion.
pubmed:affiliation
Department of Surgery, Dokkyo University School of Medicine, Tochigi, Japan.
pubmed:publicationType
Journal Article