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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5313
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pubmed:dateCreated |
1997-5-19
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pubmed:abstractText |
The human neurofibromatosis type 1 (NF1) tumor suppressor protein functions as a Ras-specific guanosine triphosphatase-activating protein, but the identity of Ras- mediated pathways modulated by NF1 remains unknown. A study of Drosophila NF1 mutants revealed that NF1 is essential for the cellular response to the neuropeptide PACAP38 (pituitary adenylyl cyclase-activating polypeptide) at the neuromuscular junction. The peptide induced a 100-fold enhancement of potassium currents by activating the Ras-Raf and adenylyl cyclase-adenosine 3',5'-monophosphate (cAMP) pathways. This response was eliminated in NF1 mutants. NF1 appears to regulate the rutabaga-encoded adenylyl cyclase rather than the Ras-Raf pathway. Moreover, the NF1 defect was rescued by the exposure of cells to pharmacological treatment that increased concentrations of cAMP.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/8-Bromo Cyclic Adenosine...,
http://linkedlifedata.com/resource/pubmed/chemical/Adenylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Bucladesine,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Forskolin,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Pituitary Adenylate...,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Pituitary Adenylate...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Pituitary Adenylate...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Pituitary Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/neurofibromin 1 protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/ras GTPase-Activating Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
276
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
795-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9115204-8-Bromo Cyclic Adenosine Monophosphate,
pubmed-meshheading:9115204-Adenylate Cyclase,
pubmed-meshheading:9115204-Animals,
pubmed-meshheading:9115204-Animals, Genetically Modified,
pubmed-meshheading:9115204-Bucladesine,
pubmed-meshheading:9115204-Cyclic AMP,
pubmed-meshheading:9115204-Drosophila,
pubmed-meshheading:9115204-Drosophila Proteins,
pubmed-meshheading:9115204-Enzyme Activation,
pubmed-meshheading:9115204-Forskolin,
pubmed-meshheading:9115204-Genes, Insect,
pubmed-meshheading:9115204-Insect Proteins,
pubmed-meshheading:9115204-Mutation,
pubmed-meshheading:9115204-Nerve Tissue Proteins,
pubmed-meshheading:9115204-Neuromuscular Junction,
pubmed-meshheading:9115204-Neuropeptides,
pubmed-meshheading:9115204-Patch-Clamp Techniques,
pubmed-meshheading:9115204-Pituitary Adenylate Cyclase-Activating Polypeptide,
pubmed-meshheading:9115204-Potassium,
pubmed-meshheading:9115204-Receptors, Pituitary Adenylate Cyclase-Activating...,
pubmed-meshheading:9115204-Receptors, Pituitary Adenylate Cyclase-Activating...,
pubmed-meshheading:9115204-Receptors, Pituitary Hormone,
pubmed-meshheading:9115204-Signal Transduction,
pubmed-meshheading:9115204-ras GTPase-Activating Proteins,
pubmed-meshheading:9115204-ras Proteins
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pubmed:year |
1997
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pubmed:articleTitle |
Requirement of Drosophila NF1 for activation of adenylyl cyclase by PACAP38-like neuropeptides.
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pubmed:affiliation |
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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