rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
1997-5-20
|
pubmed:abstractText |
Cytarabine ocfosfate (SPAC) was administered orally to 19 patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). SPAC was administered at doses of 200-300 mg/day for more than 14 days with granulocyte colony-stimulating factor (G-CSF). Four of the 12 patients with AML and 1 of the 7 patients with MDS achieved complete remission (CR) after one cycle of SPAC treatment. Especially, 3 of the 6 patients with newly diagnosed AML achieved CR. Major side effects of SPAC were myelosuppression and tolerable gastrointestinal disorders. The treatment with SPAC is a therapeutic option in elderly patients or patients with organ failure.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0925-5710
|
pubmed:author |
pubmed-author:ChuhjoTT,
pubmed-author:KatohTT,
pubmed-author:KayaHH,
pubmed-author:MatanoSS,
pubmed-author:MatsudaTT,
pubmed-author:MurashimaMM,
pubmed-author:NakamuraSS,
pubmed-author:OhtakeSS,
pubmed-author:OkumuraHH,
pubmed-author:TakamatsuHH,
pubmed-author:TakeshimaMM,
pubmed-author:WatanabeAA,
pubmed-author:YamauchiHH,
pubmed-author:YoshidaTT
|
pubmed:issnType |
Print
|
pubmed:volume |
65
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
263-8
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:9114597-Administration, Oral,
pubmed-meshheading:9114597-Adult,
pubmed-meshheading:9114597-Aged,
pubmed-meshheading:9114597-Aged, 80 and over,
pubmed-meshheading:9114597-Antineoplastic Agents,
pubmed-meshheading:9114597-Arabinonucleotides,
pubmed-meshheading:9114597-Cytidine Monophosphate,
pubmed-meshheading:9114597-Drug Therapy, Combination,
pubmed-meshheading:9114597-Female,
pubmed-meshheading:9114597-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:9114597-Humans,
pubmed-meshheading:9114597-Leukemia, Myeloid, Acute,
pubmed-meshheading:9114597-Male,
pubmed-meshheading:9114597-Middle Aged,
pubmed-meshheading:9114597-Myelodysplastic Syndromes
|
pubmed:year |
1997
|
pubmed:articleTitle |
Treatment of acute myeloid leukemia and myelodysplastic syndrome with orally administered cytarabine ocfosfate and granulocyte colony-stimulating factor.
|
pubmed:affiliation |
Department of Internal Medicine, Toyama Prefectural Central Hospital, Japan.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Multicenter Study
|