Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1997-5-27
pubmed:abstractText
Leptin is currently believed to control body composition largely, if not entirely, via hypothalamic receptors that regulate food intake and thermogenesis. Here we demonstrate direct extraneural effects of leptin to deplete fat content of both adipocytes and nonadipocytes to levels far below those of pairfed controls. In cultured pancreatic islets, leptin lowered triglyceride (TG) content by preventing TG formation from free fatty acids (FFA) and by increasing FFA oxidation. In vivo hyperleptinemia, induced in normal rats by adenovirus gene transfer, depleted TG content in liver, skeletal muscle, and pancreas without increasing plasma FFA or ketones, suggesting intracellular oxidation. In islets of obese Zucker Diabetic Fatty rats with leptin receptor mutations, leptin had no effect in vivo or in vitro. The TG content was approximately 20 times normal, and esterification capacity was increased 3- to 4-fold. Thus, in rats with normal leptin receptors but not in Zucker Diabetic Fatty rats, nonadipocytes and adipocytes esterify FFA, store them as TG, and later oxidize them intracellularly via an "indirect pathway" of intracellular fatty acid metabolism controlled by leptin. By maintaining insulin sensitivity and preventing islet lipotoxicity, this activity of leptin may prevent adipogenic diabetes.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-1334082, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-13671378, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-2965450, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-3908266, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-5498426, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-6157353, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-7004962, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-7621989, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-7713311, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-7823861, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-7836394, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-7971976, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-7984236, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-8013751, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-8464893, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-8548812, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-8616721, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-8663251, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-8673096, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-8702421, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-8702432, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-8772180, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-8782827, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-8787671, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-8962134, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-9113973, http://linkedlifedata.com/resource/pubmed/commentcorrection/9114043-987581
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
94
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4637-41
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:9114043-3-Hydroxybutyric Acid, pubmed-meshheading:9114043-Animals, pubmed-meshheading:9114043-Carrier Proteins, pubmed-meshheading:9114043-Culture Techniques, pubmed-meshheading:9114043-Diabetes Mellitus, Experimental, pubmed-meshheading:9114043-Esterification, pubmed-meshheading:9114043-Fatty Acids, Nonesterified, pubmed-meshheading:9114043-Genotype, pubmed-meshheading:9114043-Hydroxybutyrates, pubmed-meshheading:9114043-Hypoglycemic Agents, pubmed-meshheading:9114043-Islets of Langerhans, pubmed-meshheading:9114043-Leptin, pubmed-meshheading:9114043-Liver, pubmed-meshheading:9114043-Male, pubmed-meshheading:9114043-Muscle, Skeletal, pubmed-meshheading:9114043-Oxidation-Reduction, pubmed-meshheading:9114043-Proteins, pubmed-meshheading:9114043-Rats, pubmed-meshheading:9114043-Rats, Wistar, pubmed-meshheading:9114043-Rats, Zucker, pubmed-meshheading:9114043-Receptors, Cell Surface, pubmed-meshheading:9114043-Receptors, Leptin, pubmed-meshheading:9114043-Recombinant Fusion Proteins, pubmed-meshheading:9114043-Species Specificity, pubmed-meshheading:9114043-Triglycerides
pubmed:year
1997
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