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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1997-2-24
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pubmed:abstractText |
The C-terminal region of parathyroid hormone-related protein (PTHrP) containing the sequence (107-111) appears to be a potent inhibitor of osteoclastic bone resorption. In the present study, we have investigated the effect of human (h)PTHrP (107-139) and hPTHrP (107-111)NH2 on the proliferation of osteoblastic rat osteosarcoma UMR 106 cells. We found that both C-terminal PTHrP peptides, like hPTHrP (1-141), were antimitogenic for these cells, between 1 pM and 10 nM. [Tyr34]hPTHrP (1-34)NH2 was as potent as these peptides but less effective as growth inhibitor in these cells. UMR 106 cells were found to produce and secrete immunoreactive PTHrP. Addition of anti-PTHrP neutralizing antibodies to C- and N-terminal epitopes of PTHrP increased the growth of these cells. Our data suggest that the antiproliferative effect of these C-terminal PTHrP analogs may be independent of cyclic adenosine 3':5'-monophosphate (cAMP) and mediated by protein kinase C. These findings support an autocrine role of PTHrP in bone metabolism.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/PTHLH protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Parathyroid Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Parathyroid Hormone-Related Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Teriparatide,
http://linkedlifedata.com/resource/pubmed/chemical/parathyroid hormone-related...,
http://linkedlifedata.com/resource/pubmed/chemical/parathyroid hormone-related...,
http://linkedlifedata.com/resource/pubmed/chemical/parathyroid hormone-related...
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0021-9541
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
170
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
209-15
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9009150-Animals,
pubmed-meshheading:9009150-Bone Neoplasms,
pubmed-meshheading:9009150-Cell Division,
pubmed-meshheading:9009150-Cell Line,
pubmed-meshheading:9009150-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:9009150-Growth Inhibitors,
pubmed-meshheading:9009150-Humans,
pubmed-meshheading:9009150-Osteoblasts,
pubmed-meshheading:9009150-Osteosarcoma,
pubmed-meshheading:9009150-Parathyroid Hormone,
pubmed-meshheading:9009150-Parathyroid Hormone-Related Protein,
pubmed-meshheading:9009150-Peptide Fragments,
pubmed-meshheading:9009150-Protein Biosynthesis,
pubmed-meshheading:9009150-Proteins,
pubmed-meshheading:9009150-Rats,
pubmed-meshheading:9009150-Teriparatide,
pubmed-meshheading:9009150-Tumor Cells, Cultured
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pubmed:year |
1997
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pubmed:articleTitle |
Antiproliferative effect of the C-terminal fragments of parathyroid hormone-related protein, PTHrP-(107-111) and (107-139), on osteoblastic osteosarcoma cells.
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pubmed:affiliation |
Metabolic Unit Research Laboratory, Fundación Jiménez Díaz, Madrid, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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