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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1997-4-1
|
| pubmed:abstractText |
Exposure of human G0 lymphocytes to high-LET particles under different conditions has been seen, unlike low-LET radiations, to be substantially effective in the induction of sister chromatid exchanges (SCE). However, whereas for fast neutrons a linear dose response of SCE has been determined, there is no sign of a dose-response relationship for alpha-particles. A likely reason for this lack of dose dependence may be the irradiation procedure. Therefore, a technique developed in our laboratory to ensure uniformity of irradiation with alpha-particles was used in the present study. Monolayers of 3 h-stimulated lymphocytes were exposed with alpha-particles from 241Am. Underdispersion was found for the cell-to-cell variance of the number of SCE. The dose response of SCE was linear, with a yield of 3.4 SCE per cell and per Gray.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0301-634X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
35
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
311-4
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9008009-Alpha Particles,
pubmed-meshheading:9008009-DNA Damage,
pubmed-meshheading:9008009-Dose-Response Relationship, Radiation,
pubmed-meshheading:9008009-Humans,
pubmed-meshheading:9008009-Lymphocytes,
pubmed-meshheading:9008009-Male,
pubmed-meshheading:9008009-Sister Chromatid Exchange
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Dose dependent of sister chromatid exchanges in humans lymphocytes induced by in vitro alpha-particle irradiation.
|
| pubmed:affiliation |
Institut für Strahlenbiologie, GSF-Forschungszentrum für Umwelt and Gesundheit, Neuherberg, Germany.
|
| pubmed:publicationType |
Journal Article
|