| pubmed-article:8981409 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8981409 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:8981409 | lifeskim:mentions | umls-concept:C0008377 | lld:lifeskim |
| pubmed-article:8981409 | lifeskim:mentions | umls-concept:C0085262 | lld:lifeskim |
| pubmed-article:8981409 | lifeskim:mentions | umls-concept:C0596402 | lld:lifeskim |
| pubmed-article:8981409 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8981409 | lifeskim:mentions | umls-concept:C2353566 | lld:lifeskim |
| pubmed-article:8981409 | pubmed:issue | 15-17 | lld:pubmed |
| pubmed-article:8981409 | pubmed:dateCreated | 1997-4-1 | lld:pubmed |
| pubmed-article:8981409 | pubmed:abstractText | THE neurotoxic action of beta-amyloid seems to play an important role in the pathogenesis of Alzheimer's disease. The disruption of calcium homeostasis by beta-amyloid has been suspected to be the mechanism of its neurotoxicity. We found that beta-amyloid 25-35 induces a rapid increase in cytosolic calcium of PC12 cells, and subsequently, a dramatic decrease in cell viability. The increase in cytosolic calcium induced by beta-amyloid is effectively blocked by cholesterol in a dose-dependent manner. Furthermore, pretreatment of PC12 cells with cholesterol also significantly attenuates the neurotoxicity induced by beta-amyloid. These findings suggest that extracellular free cholesterol can protect neurones from beta-amyloid neurotoxicity mediated by the disruption of calcium homeostasis. | lld:pubmed |
| pubmed-article:8981409 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8981409 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8981409 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8981409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8981409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8981409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8981409 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8981409 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8981409 | pubmed:issn | 0959-4965 | lld:pubmed |
| pubmed-article:8981409 | pubmed:author | pubmed-author:RichardsonJ... | lld:pubmed |
| pubmed-article:8981409 | pubmed:author | pubmed-author:ZhouYY | lld:pubmed |
| pubmed-article:8981409 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8981409 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:8981409 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:8981409 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8981409 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8981409 | pubmed:pagination | 2487-90 | lld:pubmed |
| pubmed-article:8981409 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8981409 | pubmed:meshHeading | pubmed-meshheading:8981409-... | lld:pubmed |
| pubmed-article:8981409 | pubmed:meshHeading | pubmed-meshheading:8981409-... | lld:pubmed |
| pubmed-article:8981409 | pubmed:meshHeading | pubmed-meshheading:8981409-... | lld:pubmed |
| pubmed-article:8981409 | pubmed:meshHeading | pubmed-meshheading:8981409-... | lld:pubmed |
| pubmed-article:8981409 | pubmed:meshHeading | pubmed-meshheading:8981409-... | lld:pubmed |
| pubmed-article:8981409 | pubmed:meshHeading | pubmed-meshheading:8981409-... | lld:pubmed |
| pubmed-article:8981409 | pubmed:meshHeading | pubmed-meshheading:8981409-... | lld:pubmed |
| pubmed-article:8981409 | pubmed:meshHeading | pubmed-meshheading:8981409-... | lld:pubmed |
| pubmed-article:8981409 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8981409 | pubmed:articleTitle | Cholesterol protects PC12 cells from beta-amyloid induced calcium disordering and cytotoxicity. | lld:pubmed |
| pubmed-article:8981409 | pubmed:affiliation | Departments of Pharmacology, College of Medicine, University of Saskatchewan, Canada. | lld:pubmed |
| pubmed-article:8981409 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8981409 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8981409 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8981409 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8981409 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8981409 | lld:pubmed |
