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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1997-3-31
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pubmed:abstractText |
We studied P element-induced recombination in germline mitotic cells by examining the structure of the recombinant chromosomes. We found that most recombinants retain a mobile P element at the site of the recombination, usually with either a deletion or a duplication immediately adjacent to the P end at which the crossover occurred. The sizes of these deletions and duplications ranged from a few base pairs to well over 100 kb. These structures fit the "hybrid element insertion" (HEI) model of male recombination in which the two P-element copies on sister chromatids combine to form a "hybrid element" whose termini insert into a nearby position on the homologue. The data suggest that P-induced recombination can be used as an efficient means of generating flanking deletions in the vicinity of existing P elements. These deletions are easily screened using distant flanking markers, and they can be chosen to extend in a given direction depending on which reciprocal recombinant type is selected. Furthermore, the retention of a mobile P element allows one to extend the deletion or generate additional variability at the site by subsequent rounds of recombination.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-1313147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-1333435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-1334894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-1335623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-1418995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-1457810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-1571289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-1598205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-1653452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-1701150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-17248751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-2155155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-2155156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-2165865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-2558963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-2830671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-2835286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-3037327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-3130290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-3924725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-5277066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-6295640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-6295641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-6801436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-7672575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-7768441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-7789763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-8005411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-8114699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-8244010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-826449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-8382178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-8393572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-8413290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-8556863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-8978048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8978050-8978049
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0016-6731
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
144
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1623-38
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8978050-Animals,
pubmed-meshheading:8978050-Chromosome Mapping,
pubmed-meshheading:8978050-DNA Transposable Elements,
pubmed-meshheading:8978050-Drosophila,
pubmed-meshheading:8978050-Gene Deletion,
pubmed-meshheading:8978050-Gene Expression Regulation,
pubmed-meshheading:8978050-Male,
pubmed-meshheading:8978050-Multigene Family,
pubmed-meshheading:8978050-Recombination, Genetic,
pubmed-meshheading:8978050-Sex Determination Analysis
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pubmed:year |
1996
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pubmed:articleTitle |
Flanking duplications and deletions associated with P-induced male recombination in Drosophila.
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pubmed:affiliation |
Laboratory of Genetics, University of Wisconsin, Madison 53706, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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