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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
25
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pubmed:dateCreated |
1997-1-15
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pubmed:abstractText |
It is a long-standing proposal that localization of maternal factors in eggs can provide the basis for pattern formation in the early embryo. The localized information can be stored as RNA, one example being Vg1 RNA, which is localized exclusively to the vegetal hemisphere of Xenopus oocytes and eggs. Localization of Vg1 mRNA is directed by a 340-nt sequence element contained within its 3' untranslated region. To understand the mechanism of localization, I have tested whether factors from the oocyte interact specifically with the RNA localization sequence. Results presented here show that a set of oocyte proteins form complexes with the localization element both in vitro and in vivo. These proteins are specifically enriched in the stages of oogenesis during which localization occurs and recognize sub-elements of the RNA localization element that are essential for localization in vivo. These data suggest that formation of a localization-specific RNA-protein complex may be the first step in directing Vg1 mRNA to its subcellular destination.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-1465415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-1546297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-1638994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-1712672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-2070416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-2070417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-2170027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-2414011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-281702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-2828872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-284325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-2955216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-3200307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-3479264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-3600777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-4109871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-6207484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-7479884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-7505061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-7588639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-7684991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-7736568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-7956825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-8001156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-8223259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-8223457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-8306880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8962100-8348610
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
14608-13
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8962100-Animals,
pubmed-meshheading:8962100-Female,
pubmed-meshheading:8962100-Gene Deletion,
pubmed-meshheading:8962100-Glycoproteins,
pubmed-meshheading:8962100-Oocytes,
pubmed-meshheading:8962100-RNA, Messenger,
pubmed-meshheading:8962100-RNA-Binding Proteins,
pubmed-meshheading:8962100-Sequence Analysis,
pubmed-meshheading:8962100-Transforming Growth Factor beta,
pubmed-meshheading:8962100-Xenopus,
pubmed-meshheading:8962100-Xenopus Proteins
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pubmed:year |
1996
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pubmed:articleTitle |
Complex formation between stage-specific oocyte factors and a Xenopus mRNA localization element.
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pubmed:affiliation |
Department of Molecular Biology, Cell Biology, Biochemistry, Brown University, Providence, RI 02912, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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