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Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1996-12-19
|
pubmed:abstractText |
An overview is given of the phenotype of mice with distinct deletions of genes for cytokines and some related proteins, which occur either naturally or as a result of homologous recombination. The use of such knockout mice for investigation of the pathophysiology of experimental disease is summarized. Understanding of the role of a given cytokine in pathogenesis has therapeutic implications, as the pathology may be prevented or attenuated by inhibition of the synthesis, release or activity of that cytokine.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0959-9673
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
77
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
125-41
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:8943731-Acute-Phase Proteins,
pubmed-meshheading:8943731-Animals,
pubmed-meshheading:8943731-Arthritis, Rheumatoid,
pubmed-meshheading:8943731-Cytokines,
pubmed-meshheading:8943731-Disease Models, Animal,
pubmed-meshheading:8943731-Glomerulonephritis,
pubmed-meshheading:8943731-Humans,
pubmed-meshheading:8943731-Infection,
pubmed-meshheading:8943731-Mice,
pubmed-meshheading:8943731-Mice, Knockout,
pubmed-meshheading:8943731-Pulmonary Fibrosis,
pubmed-meshheading:8943731-Shock, Septic
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pubmed:year |
1996
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pubmed:articleTitle |
Gene knockout mice as investigative tools in pathophysiology.
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pubmed:affiliation |
Institute of Pathology, University of Basel, Switzerland.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|