Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-1-14
pubmed:abstractText
Angiotensin II (Ang II), a potent hypertrophic factor for vascular smooth muscle cells (VSMC), induces activation of the ras proto-oncogene product (Ras) and mitogen-activated protein (MAP) kinases, and tyrosine phosphorylation of a focal adhesion-associated protein, paxillin. Forskolin, a direct activator of adenylate cyclase, and dibutyryl cAMP (Bt2 cAMP), a membrane permeable cAMP analogue, potently inhibited Ang II-stimulated protein synthesis. However, they did not inhibit Ang II-induced activation of Ras and MAP kinases. Although both forskolin and Bt2 cAMP potently reduced background tyrosine phosphorylation of paxillin, they allowed Ang II to induce the same reaction. These results indicate that increasing cAMP antagonizes the hypertrophic response to Ang II without affecting Ras and MAP kinase activation in VSMC and suggest that it does not interrupt signaling from the Ang II receptor to focal adhesions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II, http://linkedlifedata.com/resource/pubmed/chemical/Bucladesine, http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent..., http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP, http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins, http://linkedlifedata.com/resource/pubmed/chemical/DNA, http://linkedlifedata.com/resource/pubmed/chemical/Forskolin, http://linkedlifedata.com/resource/pubmed/chemical/Paxillin, http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Pxn protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0014-5793
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
397
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
89-92
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:8941720-Angiotensin II, pubmed-meshheading:8941720-Animals, pubmed-meshheading:8941720-Bucladesine, pubmed-meshheading:8941720-Calcium-Calmodulin-Dependent Protein Kinases, pubmed-meshheading:8941720-Cell Adhesion Molecules, pubmed-meshheading:8941720-Cells, Cultured, pubmed-meshheading:8941720-Cyclic AMP, pubmed-meshheading:8941720-Cytoskeletal Proteins, pubmed-meshheading:8941720-DNA, pubmed-meshheading:8941720-Enzyme Activation, pubmed-meshheading:8941720-Forskolin, pubmed-meshheading:8941720-Muscle, Smooth, Vascular, pubmed-meshheading:8941720-Paxillin, pubmed-meshheading:8941720-Phosphoproteins, pubmed-meshheading:8941720-Phosphorylation, pubmed-meshheading:8941720-Protein Biosynthesis, pubmed-meshheading:8941720-Rats, pubmed-meshheading:8941720-Signal Transduction, pubmed-meshheading:8941720-ras Proteins
pubmed:year
1996
pubmed:articleTitle
Increasing cAMP antagonizes hypertrophic response to angiotensin II without affecting Ras and MAP kinase activation in vascular smooth muscle cells.
pubmed:affiliation
Department of Internal Medicine (1st Division), Kobe University School of Medicine, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't