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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
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|
pubmed:dateCreated |
1997-3-11
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|
pubmed:abstractText |
Changes in routine hematologic data and in circulating granulocyte-macrophage colony-forming units (CFU-GM) during granulocyte colony-stimulating factor (G-CSF) administration were evaluated in non-small cell lung carcinoma (NSCLC) patients treated with a combination of 5-fluorouracil (5-FU) and cisplatin (DDP) with and without the addition of interferon-alpha (IFN-alpha). The patterns of leukocyte changes following chemotherapy plus G-CSF were similar in both the IFN-alpha-inclusive and the IFN-alpha-devoid courses. However, the twofold increase in CFU-GM observed in patients receiving chemotherapy plus G-CSF was completely absent following the course including IFN-alpha. The activity of G-CSF on the hematologic pattern is seemingly affected by its combination with IFN-alpha treatment. Mechanisms of the possible in vivo interaction among IFNs and hematopoietic growth factors remain to be elucidated.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1079-9907
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
16
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
953-6
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|
pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:8938572-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:8938572-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:8938572-Cisplatin,
pubmed-meshheading:8938572-Evaluation Studies as Topic,
pubmed-meshheading:8938572-Fluorouracil,
pubmed-meshheading:8938572-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:8938572-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:8938572-Hematocrit,
pubmed-meshheading:8938572-Hematologic Tests,
pubmed-meshheading:8938572-Humans,
pubmed-meshheading:8938572-Interferon-alpha,
pubmed-meshheading:8938572-Leukocytes,
pubmed-meshheading:8938572-Lung Neoplasms,
pubmed-meshheading:8938572-Male,
pubmed-meshheading:8938572-Middle Aged,
pubmed-meshheading:8938572-Recombinant Proteins,
pubmed-meshheading:8938572-Statistics, Nonparametric
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|
pubmed:year |
1996
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|
pubmed:articleTitle |
Interferon-alpha inhibits CFU-GM mobilization following chemotherapy and G-CSF administration.
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pubmed:affiliation |
Department of Internal Medicine, University of Genoa.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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