Linked Life Data

8930990

Source:http://linkedlifedata.com/resource/pubmed/id/8930990

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
1997-3-28
pubmed:abstractText
The effects of histamine on N-methyl-d-aspartate (NMDA) receptor-mediated ion current in cultured rat cortical neurones have been investigated by superfusion of voltage-clamped (-80 mV) cells with 100 mM NMDA and with various concentrations of histamine. In a subpopulation of the neurones tested (30/53), histamine (10-100 mM) enhanced the peak amplitude, and slowed down the onset of desensitization of the NMDA-induced ion currents, both in a concentration-dependent manner. No effects of histamine on the kinetics of recovery from desensitization were detected. In other neurones (21/53), histamine had no effect on the NMDA-induced currents and in two of the neurones tested histamine potentiated NMDA-induced currents without a detectable effect on desensitization kinetics. The results indicate that in a subpopulation of rat cortical neurones histamine potentiates NMDA-induced ion currents by slowing the kinetics of onset of desensitization.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2206-10
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Histamine slows the onset of desensitization of rat cortical NMDA receptors.
pubmed:affiliation
Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Göttingen, Germany.
pubmed:publicationType
Journal Article