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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1996-10-25
|
| pubmed:abstractText |
Dopaminoceptive system alterations in the basal ganglia have been implicated in the pathogenesis of wearing-off fluctuations that complicate levodopa therapy of Parkinson's disease. To evaluate the contribution of glutamatergic mechanisms to the associated changes in striatal efferent pathway function, we examined the ability of N-methyl-D-aspartate (NMDA) receptor blockade to modify the motor response changes produced by chronic levodopa administration to hemiparkinsonian rats. Unilaterally 6-hydroxydopamine lesioned rats, given levodopa/benserazide (25/6.25 mg/kg) twice daily for 3 weeks, developed a progressive shortening in the duration of their motor response to levodopa similar to that occurring in parkinsonian patients with wearing-off phenomenon. The acute systemic administration of MK-801 (0.1 mg/kg) to these animals completely reversed the decrease in turning duration (P < 0.01). Intrastriatal injection of the NMDA antagonist was even more effective in prolonging the levodopa response (P < 0.01), while intranigrally injected MK-801 produced no statistically significant change in the duration of levodopa-induced rotation. Rotational intensity was unaffected by all routes of MK-801 administration. These results suggest that drugs capable of blocking NMDA receptors, especially in striatum, may help ameliorate motor fluctuations in patients with advanced Parkinson's disease.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antiparkinson Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Apomorphine,
http://linkedlifedata.com/resource/pubmed/chemical/Benserazide,
http://linkedlifedata.com/resource/pubmed/chemical/Dizocilpine Maleate,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Levodopa,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidopamine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0006-8993
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
701
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
13-8
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8925275-Animals,
pubmed-meshheading:8925275-Antiparkinson Agents,
pubmed-meshheading:8925275-Apomorphine,
pubmed-meshheading:8925275-Benserazide,
pubmed-meshheading:8925275-Dizocilpine Maleate,
pubmed-meshheading:8925275-Excitatory Amino Acid Antagonists,
pubmed-meshheading:8925275-Injections,
pubmed-meshheading:8925275-Injections, Intraventricular,
pubmed-meshheading:8925275-Levodopa,
pubmed-meshheading:8925275-Male,
pubmed-meshheading:8925275-Movement,
pubmed-meshheading:8925275-Oxidopamine,
pubmed-meshheading:8925275-Parkinson Disease, Secondary,
pubmed-meshheading:8925275-Rats,
pubmed-meshheading:8925275-Rats, Sprague-Dawley,
pubmed-meshheading:8925275-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:8925275-Rotation,
pubmed-meshheading:8925275-Stereotyped Behavior,
pubmed-meshheading:8925275-Substantia Nigra
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Reversal of levodopa-induced motor fluctuations in experimental parkinsonism by NMDA receptor blockade.
|
| pubmed:affiliation |
Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA.
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| pubmed:publicationType |
Journal Article
|