Linked Life Data

8915512

Source:http://linkedlifedata.com/resource/pubmed/id/8915512

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1997-2-19
pubmed:abstractText
Sixteen male and female patients with alcoholic cirrhosis and 13 healthy controls were included in the study. The level of interferon (IFN) and tumor necrosis factor (TNF) activity was examined in the sera and also in cultures in peripheral blood leukocytes (PBL) after in vitro stimulation with the cytokine inducers. In sera of patients with alcoholic cirrhosis higher IFN and TNF levels were detected than in controls. However, after induction with Newcastle disease virus (NDV), phytohemagglutinin M (PHA) and lipopolysaccharide from E. coli (LPS), PBL from cirrhotic patients produced lower IFN levels in comparison to controls. In contrast to depressed ability to produce IFNs, TNF production was higher in PBL of cirrhotic patients induced by PHA and a low dose of LPS (1 microgram/ml). NDV induced comparable levels of TNF in both groups. It appears likely that cells of cirrhotic patients were suppressed by an unknown factor or were hyporeactive for IFN production, but synthesis and release of TNF was enhanced, suggesting that cells producing TNF were preactivated in vivo. Mechanism of such preactivation is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0004-069X
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
97-101
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Tumor necrosis factor and interferon production by peripheral blood leukocytes of patients with alcoholic cirrhosis.
pubmed:affiliation
Department and Clinic of Gastroenterology, Medical Academy, Lublin, Poland.
pubmed:publicationType
Journal Article