rdf:type |
|
lifeskim:mentions |
umls-concept:C0007271,
umls-concept:C0009368,
umls-concept:C0021469,
umls-concept:C0034693,
umls-concept:C0043328,
umls-concept:C0051336,
umls-concept:C0053396,
umls-concept:C0065331,
umls-concept:C0205296,
umls-concept:C1280500,
umls-concept:C1522492,
umls-concept:C1879526
|
pubmed:issue |
1
|
pubmed:dateCreated |
1996-12-5
|
pubmed:abstractText |
Inhibitory effect of four carotenoids prevalent in human blood and tissues against the formation of colonic aberrant crypt foci was examined in Sprague-Dawley rats. They received three intrarectal doses of N-methylnitrosourea in weak 1, and a daily gavage of de-escalated doses of carotenoids during weeks 2 and 5. Lycopene, lutein, alpha-carotene and palm carotenes (a mixture of alpha-carotene, beta-carotene and lycopene) inhibited the development of aberrant crypt foci quantitated at week 6, but beta-carotene did not. The results suggested that lycopene and lutein in small doses may potentially prevent colon carcinogenesis.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0304-3835
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
107
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
137-42
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:8913278-Animals,
pubmed-meshheading:8913278-Anticarcinogenic Agents,
pubmed-meshheading:8913278-Carotenoids,
pubmed-meshheading:8913278-Colonic Neoplasms,
pubmed-meshheading:8913278-Female,
pubmed-meshheading:8913278-Intestinal Mucosa,
pubmed-meshheading:8913278-Lutein,
pubmed-meshheading:8913278-Neoplasms, Experimental,
pubmed-meshheading:8913278-Precancerous Conditions,
pubmed-meshheading:8913278-Rats,
pubmed-meshheading:8913278-Rats, Sprague-Dawley,
pubmed-meshheading:8913278-beta Carotene
|
pubmed:year |
1996
|
pubmed:articleTitle |
Inhibitory effects of natural carotenoids, alpha-carotene, beta-carotene, lycopene and lutein, on colonic aberrant crypt foci formation in rats.
|
pubmed:affiliation |
Akita University College of Allied Medical Science, Japan.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|