Linked Life Data

8913033

Source:http://linkedlifedata.com/resource/pubmed/id/8913033

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1996-12-11
pubmed:abstractText
Pulses of the steroid hormone 20-hydroxyecdysone (ecdysone) regulate diverse biological responses during the life history of insects. Studies of the fruit fly, Drosophila melanogaster, have provided significant insights into the mechanisms underlying ecdysone mediated regulation of development. During the dramatic metamorphosis of Drosophila, ecdysone induces the histolysis of nearly all of the larval tissues and differentiation and morphogenesis of the structures composing the adult fly. These changes are mediated by a genetic signaling cascade that was first recognized as puffs in the giant polytene chromosomes of the salivary gland. This genetic regulatory cascade is composed of early and late genes that are intricately coordinated by changes in hormone titer. Early genes encode regulatory proteins that are involved in the proper regulation of late genes, which are thought to play a more direct role in development. The regulation and function of these genes is discussed in the context of the cell- and tissue-specific changes required for the reorganization of a larva to form an adult fly.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0739-4462
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
231-44
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Ecdysone signaling cascade and regulation of Drosophila metamorphosis.
pubmed:affiliation
Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park 20742, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Review, Research Support, Non-U.S. Gov't