| pubmed-article:8910424 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8910424 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:8910424 | lifeskim:mentions | umls-concept:C0007765 | lld:lifeskim |
| pubmed-article:8910424 | lifeskim:mentions | umls-concept:C0596630 | lld:lifeskim |
| pubmed-article:8910424 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:8910424 | lifeskim:mentions | umls-concept:C0070099 | lld:lifeskim |
| pubmed-article:8910424 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:8910424 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:8910424 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:8910424 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:8910424 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:8910424 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:8910424 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:8910424 | lifeskim:mentions | umls-concept:C2348693 | lld:lifeskim |
| pubmed-article:8910424 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:8910424 | pubmed:issue | 45 | lld:pubmed |
| pubmed-article:8910424 | pubmed:dateCreated | 1996-12-30 | lld:pubmed |
| pubmed-article:8910424 | pubmed:abstractText | Parathyroid hormone (PTH)-related peptide (PTHrP) is expressed in the adult mammalian brain, but its function is unknown. Here we show that PTHrP and the PTH/PTHrP receptor are products of cerebellar granule cells in primary culture. Granule cells maintained under depolarizing conditions (25 mM K+) make and release PTHrP. Further, PTHrP-(1-36) stimulates cAMP accumulation in granule neurons in a dose-dependent manner with half-maximal activation at approximately 16 nM. Granule cell PTHrP mRNA is activity-dependent, and the pathway of regulation depends absolutely on the flux of Ca2+ ions through the L-type voltage-sensitive Ca2+ channel and the Ca2+/calmodulin kinase cascade. PTHrP is therefore a neuropeptide whose regulation depends upon L-type voltage-sensitive Ca2+ channel activity, and the gene is expressed under conditions that promote granule cell survival. | lld:pubmed |
| pubmed-article:8910424 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8910424 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8910424 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8910424 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8910424 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8910424 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8910424 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8910424 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8910424 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8910424 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8910424 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8910424 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8910424 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8910424 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8910424 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8910424 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8910424 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:8910424 | pubmed:author | pubmed-author:BroadusA EAE | lld:pubmed |
| pubmed-article:8910424 | pubmed:author | pubmed-author:LEESA DAD | lld:pubmed |
| pubmed-article:8910424 | pubmed:author | pubmed-author:BrinesM LML | lld:pubmed |
| pubmed-article:8910424 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8910424 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:8910424 | pubmed:volume | 271 | lld:pubmed |
| pubmed-article:8910424 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8910424 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8910424 | pubmed:pagination | 28105-11 | lld:pubmed |
| pubmed-article:8910424 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:8910424 | pubmed:meshHeading | pubmed-meshheading:8910424-... | lld:pubmed |
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| pubmed-article:8910424 | pubmed:meshHeading | pubmed-meshheading:8910424-... | lld:pubmed |
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| pubmed-article:8910424 | pubmed:meshHeading | pubmed-meshheading:8910424-... | lld:pubmed |
| pubmed-article:8910424 | pubmed:meshHeading | pubmed-meshheading:8910424-... | lld:pubmed |
| pubmed-article:8910424 | pubmed:meshHeading | pubmed-meshheading:8910424-... | lld:pubmed |
| pubmed-article:8910424 | pubmed:meshHeading | pubmed-meshheading:8910424-... | lld:pubmed |
| pubmed-article:8910424 | pubmed:meshHeading | pubmed-meshheading:8910424-... | lld:pubmed |
| pubmed-article:8910424 | pubmed:meshHeading | pubmed-meshheading:8910424-... | lld:pubmed |
| pubmed-article:8910424 | pubmed:meshHeading | pubmed-meshheading:8910424-... | lld:pubmed |
| pubmed-article:8910424 | pubmed:meshHeading | pubmed-meshheading:8910424-... | lld:pubmed |
| pubmed-article:8910424 | pubmed:meshHeading | pubmed-meshheading:8910424-... | lld:pubmed |
| pubmed-article:8910424 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8910424 | pubmed:articleTitle | Parathyroid hormone-related peptide is produced by cultured cerebellar granule cells in response to L-type voltage-sensitive Ca2+ channel flux via a Ca2+/calmodulin-dependent kinase pathway. | lld:pubmed |
| pubmed-article:8910424 | pubmed:affiliation | Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520-8020, USA. | lld:pubmed |
| pubmed-article:8910424 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8910424 | lld:pubmed |
