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rdf:type |
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lifeskim:mentions |
umls-concept:C0007765,
umls-concept:C0010453,
umls-concept:C0031727,
umls-concept:C0070099,
umls-concept:C0439799,
umls-concept:C0596235,
umls-concept:C0596630,
umls-concept:C0871261,
umls-concept:C1704259,
umls-concept:C1704632,
umls-concept:C1705987,
umls-concept:C1706817,
umls-concept:C2348693,
umls-concept:C2911692
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pubmed:issue |
45
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pubmed:dateCreated |
1996-12-30
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pubmed:abstractText |
Parathyroid hormone (PTH)-related peptide (PTHrP) is expressed in the adult mammalian brain, but its function is unknown. Here we show that PTHrP and the PTH/PTHrP receptor are products of cerebellar granule cells in primary culture. Granule cells maintained under depolarizing conditions (25 mM K+) make and release PTHrP. Further, PTHrP-(1-36) stimulates cAMP accumulation in granule neurons in a dose-dependent manner with half-maximal activation at approximately 16 nM. Granule cell PTHrP mRNA is activity-dependent, and the pathway of regulation depends absolutely on the flux of Ca2+ ions through the L-type voltage-sensitive Ca2+ channel and the Ca2+/calmodulin kinase cascade. PTHrP is therefore a neuropeptide whose regulation depends upon L-type voltage-sensitive Ca2+ channel activity, and the gene is expressed under conditions that promote granule cell survival.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Parathyroid Hormone-Related Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Parathyroid Hormone...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Parathyroid Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Veratridine,
http://linkedlifedata.com/resource/pubmed/chemical/calcium-dependent protein kinase
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
271
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
28105-11
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8910424-Animals,
pubmed-meshheading:8910424-Calcium,
pubmed-meshheading:8910424-Calcium Channels,
pubmed-meshheading:8910424-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:8910424-Cells, Cultured,
pubmed-meshheading:8910424-Cerebellum,
pubmed-meshheading:8910424-Female,
pubmed-meshheading:8910424-Parathyroid Hormone-Related Protein,
pubmed-meshheading:8910424-Potassium,
pubmed-meshheading:8910424-Protein Biosynthesis,
pubmed-meshheading:8910424-Protein Kinases,
pubmed-meshheading:8910424-RNA, Messenger,
pubmed-meshheading:8910424-Rats,
pubmed-meshheading:8910424-Rats, Sprague-Dawley,
pubmed-meshheading:8910424-Receptor, Parathyroid Hormone, Type 1,
pubmed-meshheading:8910424-Receptors, Parathyroid Hormone,
pubmed-meshheading:8910424-Veratridine
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pubmed:year |
1996
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pubmed:articleTitle |
Parathyroid hormone-related peptide is produced by cultured cerebellar granule cells in response to L-type voltage-sensitive Ca2+ channel flux via a Ca2+/calmodulin-dependent kinase pathway.
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pubmed:affiliation |
Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520-8020, USA.
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pubmed:publicationType |
Journal Article
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