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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
|
pubmed:dateCreated |
1997-3-25
|
pubmed:abstractText |
The t(11;14) (q13;q32) translocation and its molecular counterpart Bcl-1 rearrangement are consistent features of mantle cell lymphoma (MCL). This translocation activates the PRAD1/cyclin D1 gene that is considered to be the Bcl-1 oncogene. PRAD1/cyclin D1 gene overexpression is closely associated with MCL. The PRAD1/cyclin D1 protein is localized to the nucleus, and the strong correlation between PRAD1/cyclin D1 and MCL is also found in the protein level. This finding indicates that PRAD1/cyclin D1 expression is a highly specific and sensitive molecular marker for MCL. This gene may function as an oncogene in the malignant transformation of cells.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
1042-8194
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
21
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
37-42
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pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading | |
pubmed:year |
1996
|
pubmed:articleTitle |
PRAD1/Cyclin D1 gene overexpression in mantle cell lymphoma.
|
pubmed:affiliation |
The Second Department of Internal Medicine, Mie University School of Medicine, Edobashi Tsu, Japan.
|
pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|