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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1997-2-13
|
| pubmed:abstractText |
The one-electron reduction potential of 3-amino-1,2,4-benzotriazine 1,4-dioxide, tirapazamine (SR 4233) in aqueous solution has been determined by pulse radiolysis. Reversible electron transfer was achieved between radiolytically-generated one-electron reduced radicals of tirapazamine (T), and quinones or benzyl viologen as redox standards. The reduction potential Em7(T/T-) was -0.45 +/- 0.01 V vs. NHE at pH 7 From the pH dependence of the reduction potential, pKa = 5.6 +/- 0.2 was estimated for the tirapazamine radical, a value similar to the pKa determined by other methods.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1071-5762
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
393-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8902537-Benzyl Viologen,
pubmed-meshheading:8902537-Cell Hypoxia,
pubmed-meshheading:8902537-Electron Transport,
pubmed-meshheading:8902537-Hydrogen-Ion Concentration,
pubmed-meshheading:8902537-Oxidation-Reduction,
pubmed-meshheading:8902537-Pulse Radiolysis,
pubmed-meshheading:8902537-Triazines
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
The one-electron reduction potential of 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine): a hypoxia-selective bioreductive drug.
|
| pubmed:affiliation |
Gray Laboratory Cancer Research Trust, Mouni Vernon Hospital, Northwood, Middx, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|