Source:http://linkedlifedata.com/resource/umls/id/C0208407
CSP: antineoplastic, radiation sensitizing agent; 3-amino1,2,4-benzotriazine 1,4-dioxide.,NCI: A drug that makes tumor cells more sensitive to radiation therapy.,PDQ: A benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free radicals in hypoxic cells, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair of radiation-induced DNA strand breaks via inhibition of topoisomerase II. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42158&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42158&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1464" NCI Thesaurus),NCI: A benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selecti