Linked Life Data

8894304

Source:http://linkedlifedata.com/resource/pubmed/id/8894304

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1997-2-6
pubmed:abstractText
Drosophila melanogaster, an insect amenable to convenient molecular and genetic manipulation, has a highly sensitive olfactory system. A number of Drosophila olfactory mutants have been isolated and characterized. The smellblind mutant has a defect affecting a voltage-gated Na+ channel. The norpA mutant, defective in a phospholipase C, has a reduced response to odorants in one type of olfactory organ, providing genetic evidence for use of the inositol-1,4,5-trisphosphate signal transduction pathway in olfaction. Since the norpA gene is also required for phototransduction, this work demonstrates overlap in the molecular genetic basis of vision and olfaction. Interestingly, genetic analysis indicates that some olfactory information flows through a pathway which does not depend on norpA. Some mutants, such as ptg, acj6 and Sco, show odorant specificity, in the sense that some odorant responses are greatly reduced, whereas others are little affected, if at all. Some, but not all, mutations affect both larval and adult olfactory responses. Two tightly-linked Drosophila genes encode homologues of moth pheromone-binding proteins (PBPs). Genetic analysis may help determine whether PBPs facilitate transit of pheromones to or from olfactory receptor neurons. Information from Drosophila could be useful in designing means of controlling mosquitoes. It may also be possible to study olfactory genes, such as those encoding PBPs, from other insects by mutating them, introducing them into Drosophila and analysing their function in vivo.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-5208
pubmed:author
pubmed:issnType
Print
pubmed:volume
200
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
285-96; discussion 296-301
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Genetic and molecular studies of olfaction in Drosophila.
pubmed:affiliation
Department of Biology, Yale University, New Haven, CT 06520-8103, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Review, Research Support, Non-U.S. Gov't