Linked Life Data

8892938

Source:http://linkedlifedata.com/resource/pubmed/id/8892938

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1996-12-30
pubmed:abstractText
Poliovirus vectors are being studied as potential vaccine delivery systems, with foreign genetic sequences incorporated as part of the viral genome. The foreign sequences are expressed as part of the viral polyprotein. Addition of proteolytic cleavage sites at the junction of the foreign polypeptide and the viral proteins results in cleavage during polyprotein processing. The ability of foot-and-mouth disease virus (FMDV) 2A to mediate proteolytic cleavage in the context of poliovirus vectors was studied. The results demonstrate that FMDV 2A is able to generate cleavage of the foreign antigen from the viral polyprotein. A second cleavage event between the FMDV 2A peptide and the foreign protein was also observed.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8892938-1313923, http://linkedlifedata.com/resource/pubmed/commentcorrection/8892938-1318418, http://linkedlifedata.com/resource/pubmed/commentcorrection/8892938-1658199, http://linkedlifedata.com/resource/pubmed/commentcorrection/8892938-2467994, http://linkedlifedata.com/resource/pubmed/commentcorrection/8892938-2542331, http://linkedlifedata.com/resource/pubmed/commentcorrection/8892938-2659276, http://linkedlifedata.com/resource/pubmed/commentcorrection/8892938-2846581, http://linkedlifedata.com/resource/pubmed/commentcorrection/8892938-3010307, http://linkedlifedata.com/resource/pubmed/commentcorrection/8892938-3035380, http://linkedlifedata.com/resource/pubmed/commentcorrection/8892938-307445, http://linkedlifedata.com/resource/pubmed/commentcorrection/8892938-6740074, http://linkedlifedata.com/resource/pubmed/commentcorrection/8892938-7609083, http://linkedlifedata.com/resource/pubmed/commentcorrection/8892938-7645249, http://linkedlifedata.com/resource/pubmed/commentcorrection/8892938-8112307, http://linkedlifedata.com/resource/pubmed/commentcorrection/8892938-8189529, http://linkedlifedata.com/resource/pubmed/commentcorrection/8892938-8207822, http://linkedlifedata.com/resource/pubmed/commentcorrection/8892938-8380894
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8124-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Foot-and-mouth disease virus 2A protease mediates cleavage in attenuated Sabin 3 poliovirus vectors engineered for delivery of foreign antigens.
pubmed:affiliation
Wyeth-Lederle Vaccines and Pediatrics, Viral Vaccine Research, Pearl River, New York 10965, USA. nmattion@virol.wamani.apc.org.
pubmed:publicationType
Journal Article