| pubmed-article:8879183 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8879183 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8879183 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:8879183 | lifeskim:mentions | umls-concept:C0143146 | lld:lifeskim |
| pubmed-article:8879183 | lifeskim:mentions | umls-concept:C0017270 | lld:lifeskim |
| pubmed-article:8879183 | lifeskim:mentions | umls-concept:C0079429 | lld:lifeskim |
| pubmed-article:8879183 | lifeskim:mentions | umls-concept:C1420002 | lld:lifeskim |
| pubmed-article:8879183 | lifeskim:mentions | umls-concept:C0023746 | lld:lifeskim |
| pubmed-article:8879183 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8879183 | pubmed:dateCreated | 1996-12-3 | lld:pubmed |
| pubmed-article:8879183 | pubmed:abstractText | Two surfactant protein A (SP-A) genes and several alleles for each SP-A locus have been previously described. In this report we investigate the potential usefulness of the SP-A loci as markers for genetic studies. We establish conditions that allow the identification of alleles with very similar sequences; We also determine the degree of polymorphism for each SP-A locus: The heterozygosity and polymorphism information content (PIC) values for the SP-A1 locus are 0.63 and 0.55, respectively, and for the SP-A2 locus are 0.50 and 0.56. In the course of these studies, we identify one new SP-A2 allele and show that the SP-A1 and SP-A2 loci are in linkage disequilibrium (P < 0.000001). We also identify 19 of the 20 possible haplotypes in a population of n = 239. Nine of the observed haplotypes reach statistical significance (P < 0.01) in this population, and the segregation of two haplotypes (6A2/1A0 and 6A4/1A) without recombination is verified in a family pedigree. These data together indicate that both SP-A loci are sufficiently polymorphic to be good markers for use in genetic studies. Furthermore, the finding of one novel allele suggests that additional unknown SP-A alleles are yet to be found. | lld:pubmed |
| pubmed-article:8879183 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8879183 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8879183 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8879183 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8879183 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8879183 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8879183 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8879183 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8879183 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8879183 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8879183 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8879183 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8879183 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8879183 | pubmed:issn | 1044-1549 | lld:pubmed |
| pubmed-article:8879183 | pubmed:author | pubmed-author:NielsenHH | lld:pubmed |
| pubmed-article:8879183 | pubmed:author | pubmed-author:DeitelMM | lld:pubmed |
| pubmed-article:8879183 | pubmed:author | pubmed-author:FlorosJJ | lld:pubmed |
| pubmed-article:8879183 | pubmed:author | pubmed-author:SpraggR GRG | lld:pubmed |
| pubmed-article:8879183 | pubmed:author | pubmed-author:KoptidesMM | lld:pubmed |
| pubmed-article:8879183 | pubmed:author | pubmed-author:RoganP KPK | lld:pubmed |
| pubmed-article:8879183 | pubmed:author | pubmed-author:KarinchA MAM | lld:pubmed |
| pubmed-article:8879183 | pubmed:author | pubmed-author:DiAngeloSS | lld:pubmed |
| pubmed-article:8879183 | pubmed:author | pubmed-author:WatterbergKK | lld:pubmed |
| pubmed-article:8879183 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8879183 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:8879183 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8879183 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8879183 | pubmed:pagination | 489-98 | lld:pubmed |
| pubmed-article:8879183 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:8879183 | pubmed:meshHeading | pubmed-meshheading:8879183-... | lld:pubmed |
| pubmed-article:8879183 | pubmed:meshHeading | pubmed-meshheading:8879183-... | lld:pubmed |
| pubmed-article:8879183 | pubmed:meshHeading | pubmed-meshheading:8879183-... | lld:pubmed |
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| pubmed-article:8879183 | pubmed:meshHeading | pubmed-meshheading:8879183-... | lld:pubmed |
| pubmed-article:8879183 | pubmed:meshHeading | pubmed-meshheading:8879183-... | lld:pubmed |
| pubmed-article:8879183 | pubmed:meshHeading | pubmed-meshheading:8879183-... | lld:pubmed |
| pubmed-article:8879183 | pubmed:meshHeading | pubmed-meshheading:8879183-... | lld:pubmed |
| pubmed-article:8879183 | pubmed:meshHeading | pubmed-meshheading:8879183-... | lld:pubmed |
| pubmed-article:8879183 | pubmed:meshHeading | pubmed-meshheading:8879183-... | lld:pubmed |
| pubmed-article:8879183 | pubmed:meshHeading | pubmed-meshheading:8879183-... | lld:pubmed |
| pubmed-article:8879183 | pubmed:meshHeading | pubmed-meshheading:8879183-... | lld:pubmed |
| pubmed-article:8879183 | pubmed:meshHeading | pubmed-meshheading:8879183-... | lld:pubmed |
| pubmed-article:8879183 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8879183 | pubmed:articleTitle | Human SP-A locus: allele frequencies and linkage disequilibrium between the two surfactant protein A genes. | lld:pubmed |
| pubmed-article:8879183 | pubmed:affiliation | Department of Cellular and Molecular Physiology, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, 17033-0850, USA. | lld:pubmed |
| pubmed-article:8879183 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8879183 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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