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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0017262,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0034790,
umls-concept:C0079189,
umls-concept:C0330390,
umls-concept:C0384648,
umls-concept:C1171362,
umls-concept:C1515670,
umls-concept:C2003941
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pubmed:issue |
8
|
|
pubmed:dateCreated |
1997-2-6
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pubmed:databankReference |
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pubmed:abstractText |
A novel cytokine originally designated murine CTLA-8 was described as a cDNA isolated from an activated T cell hybridoma produced by fusing a mouse cytotoxic T cell clone and a rat T lymphoma. This cDNA, which contains mRNA instability sequences characteristic of many cytokines, encoded a putative secreted protein that was homologous to the ORF13 gene of Herpesvirus saimiri. The human homolog to this molecule has recently been identified as the proinflammatory cytokine IL-17. We describe the isolation of a cDNA encoding mouse IL-17 from a cDNA library generated from alpha beta TCR + CD4-CD8- thymocytes using a subtraction technique that enriched for activation specific genes. This cDNA shares 87.3% amino acid identity to the previously described murine CTLA-8. Comparison of murine CTLA-8 to a cDNA we isolated from activated rat splenocytes revealed that murine CTLA-8 is, in fact, the rat homolog of IL-17. Mouse IL-17 mRNA is specifically expressed by activated alpha beta TCR + CD4-CD8- T cells, a small subset with a potentially important role in immune regulation. Mouse, rat, and human IL-17 can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor.
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
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pubmed:issn |
1079-9907
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
16
|
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
611-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8877732-Animals,
pubmed-meshheading:8877732-Bone Marrow Cells,
pubmed-meshheading:8877732-Connective Tissue,
pubmed-meshheading:8877732-DNA, Complementary,
pubmed-meshheading:8877732-Gene Library,
pubmed-meshheading:8877732-Genes,
pubmed-meshheading:8877732-Humans,
pubmed-meshheading:8877732-Interleukin-17,
pubmed-meshheading:8877732-Interleukin-6,
pubmed-meshheading:8877732-Interleukins,
pubmed-meshheading:8877732-Mice,
pubmed-meshheading:8877732-Mice, Inbred BALB C,
pubmed-meshheading:8877732-Molecular Sequence Data,
pubmed-meshheading:8877732-Rats,
pubmed-meshheading:8877732-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:8877732-Recombinant Fusion Proteins,
pubmed-meshheading:8877732-Sequence Alignment,
pubmed-meshheading:8877732-Sequence Homology,
pubmed-meshheading:8877732-Species Specificity,
pubmed-meshheading:8877732-Subtraction Technique,
pubmed-meshheading:8877732-T-Lymphocyte Subsets,
pubmed-meshheading:8877732-Tumor Cells, Cultured
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|
pubmed:year |
1996
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|
pubmed:articleTitle |
Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells.
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|
pubmed:affiliation |
Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
