Linked Life Data

8856443

Source:http://linkedlifedata.com/resource/pubmed/id/8856443

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1996-12-5
pubmed:abstractText
Two 15-d nutrient balance trials were conducted using a total of 32 weanling barrows (averaging 6.8 kg, 26 d). The effect of the addition of 15 or 250 ppm Cu (as CuSO4.5H2O) to diets containing 0 or 5% added animal fat on nutrient utilization, digestive enzyme activities, and tissue mineral levels in weanling pigs was investigated. In each trial, four groups of four littermate barrows were randomly assigned to one of four treatments in a 2 x 2 factorial arrangement. The addition of 250 ppm Cu improved apparent fat digestibility and apparent nitrogen retention (P < .02). The addition of 5% fat increased apparent fat digestibility (P < .01). There were no Cu x fat interactions (P > .10) for any of the digestibility indices measured. The addition of 250 ppm of Cu stimulated small intestinal lipase (P < .01) and phospholipase A (P < .05) activities but had no effect (P > .10) on pancreatic lipase or phospholipase activities and no effect on trypsin, chymotrypsin, or amylase activities in the small intestine or the pancreas. The addition of 250 ppm Cu to the diet increased Cu (P < .001) in plasma, liver, and kidney and decreased Fe in plasma (P < .05) and liver (P < .02). The addition of 5% fat increased Fe in kidney (P < .05) and heart (P < .08). Copper x fat interactions were observed for spleen Ca (P < .01), Mg (P < .08), Na (P < .05), and K (P < .08) and spleen weight (P < .05). In additional in vitro assays, increased Cu concentrations tended to consistently stimulate purified porcine pancreatic lipase activity (linear, P < .01) but not purified porcine pancreatic phospholipase A activity (P > .10). The results from this study indicate that 250 ppm Cu stimulated intestinal lipase and phospholipase A activities, leading to an improvement of dietary fat digestibility in weanling pigs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0021-8812
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1888-96
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Effect of dietary copper and fat on nutrient utilization, digestive enzyme activities, and tissue mineral levels in weanling pigs.
pubmed:affiliation
Department of Animal and Dairy Science, College of Agriculture and Environmental Sciences, University of Georgia, Tifton 31793-0748, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't