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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
1996-11-25
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pubmed:abstractText |
Interleukin 1 receptor antagonist (IL-1ra) is a cytokine whose only known action is competitive inhibition of the binding of interleukin 1 (IL-1) to its receptor. To investigate the physiological roles of endogenously produced IL-1ra, we generated mice that either lack IL-1ra or overproduce it under control of the endogenous promoter. Mice lacking IL-1ra have decreased body mass compared with wild-type controls. They are more susceptible than controls to lethal endotoxemia but are less susceptible to infection with Listeria monocytogenes. Conversely, IL-1ra overproducers are protected from the lethal effects of endotoxin but are more susceptible to listeriosis. Serum levels of IL-1 following an endotoxin challenge are decreased in IL-1ra nulls and increased in IL-1ra overproducers in comparison to controls. These data demonstrate critical roles for endogenously produced IL-1ra in growth, responses to infection and inflammation, and regulation of cytokine expression.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-1387669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-1531270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-1531668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-1533231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-1533322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-1533323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-1828071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-1834576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-2137200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-2147233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-2448381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-2901567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-3290384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-3497982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-3497983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-7594609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-7600191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-7616110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-7621081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-7629520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-7727685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-7775431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-7859282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-8003626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-8040288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-8051414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-8196140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-8376799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-8379462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-8432613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855299-8552648
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11008-13
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8855299-Animals,
pubmed-meshheading:8855299-Endotoxemia,
pubmed-meshheading:8855299-Gene Expression,
pubmed-meshheading:8855299-Interleukin 1 Receptor Antagonist Protein,
pubmed-meshheading:8855299-Interleukin-1,
pubmed-meshheading:8855299-Interleukin-6,
pubmed-meshheading:8855299-Lipopolysaccharides,
pubmed-meshheading:8855299-Listeria monocytogenes,
pubmed-meshheading:8855299-Listeriosis,
pubmed-meshheading:8855299-Mice,
pubmed-meshheading:8855299-Mice, Inbred C57BL,
pubmed-meshheading:8855299-Mice, Knockout,
pubmed-meshheading:8855299-Sialoglycoproteins,
pubmed-meshheading:8855299-Survival Analysis
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pubmed:year |
1996
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pubmed:articleTitle |
Functions of interleukin 1 receptor antagonist in gene knockout and overproducing mice.
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pubmed:affiliation |
Department of Biochemistry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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