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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1996-12-4
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pubmed:abstractText |
We previously demonstrated that tumor necrosis factor-alpha (TNF-alpha) induces rapid human neutrophil apoptosis. In this paper, we examined which of the TNF receptors, p55 kDa TNF receptor (55-R) or p75 kDa TNF receptor (75-R), or both are involved in this process using specific rabbit antisera. Antibodies to 55-R (anti55-R) or 75-R (anti75-R) alone did not induce neutrophil apoptosis. Further addition of cycloheximide and anti-rabbit immunoglobulin to anti55-R but not to anti75-R accelerated apoptosis, although anti75-R augmented the capacity of anti55-R to do so. These results suggest that 55-R is a prerequisite for TNF-alpha induced neutrophil apoptosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0385-5600
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
463-5
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:8839434-Animals,
pubmed-meshheading:8839434-Antigens, CD,
pubmed-meshheading:8839434-Apoptosis,
pubmed-meshheading:8839434-Humans,
pubmed-meshheading:8839434-Neutrophils,
pubmed-meshheading:8839434-Rabbits,
pubmed-meshheading:8839434-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:8839434-Receptors, Tumor Necrosis Factor, Type I,
pubmed-meshheading:8839434-Receptors, Tumor Necrosis Factor, Type II,
pubmed-meshheading:8839434-Tumor Necrosis Factor-alpha
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pubmed:year |
1996
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pubmed:articleTitle |
Involvement of two types of TNF receptor in TNF-alpha induced neutrophil apoptosis.
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pubmed:affiliation |
Department of Immunology and Parasitology, Yamagata University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article
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