| pubmed-article:8837611 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8837611 | lifeskim:mentions | umls-concept:C0020971 | lld:lifeskim |
| pubmed-article:8837611 | lifeskim:mentions | umls-concept:C0040669 | lld:lifeskim |
| pubmed-article:8837611 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:8837611 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:8837611 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:8837611 | pubmed:dateCreated | 1996-11-4 | lld:pubmed |
| pubmed-article:8837611 | pubmed:abstractText | Delivery of antigen in a manner that induces effective, antigen-specific immunity is a critical challenge in vaccine design. Optimal antigen presentation is mediated by professional antigen-presenting cells (APCs) capable of taking up, processing and presenting antigen to T cells in the context of costimulatory signals required for T-cell activation. Developing immunization strategies to optimize antigen presentation by dendritic cells, the most potent APCs, is a rational approach to vaccine design. Here we show that cutaneous genetic immunization with naked DNA results in potent, antigen-specific, cytotoxic T lymphocyte-mediated protective tumor immunity. This method of immunization results in the transfection of skin-derived dendritic cells, which localize in the draining lymph nodes. These observations provide a basis for further development of DNA-based vaccines and demonstrate the feasibility of genetically engineering dendritic cells in vivo. | lld:pubmed |
| pubmed-article:8837611 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8837611 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8837611 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8837611 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8837611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8837611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8837611 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8837611 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8837611 | pubmed:issn | 1078-8956 | lld:pubmed |
| pubmed-article:8837611 | pubmed:author | pubmed-author:ThompsonKK | lld:pubmed |
| pubmed-article:8837611 | pubmed:author | pubmed-author:DatiTT | lld:pubmed |
| pubmed-article:8837611 | pubmed:author | pubmed-author:CondonCC | lld:pubmed |
| pubmed-article:8837611 | pubmed:author | pubmed-author:WatkinsS CSC | lld:pubmed |
| pubmed-article:8837611 | pubmed:author | pubmed-author:CelluzziC MCM | lld:pubmed |
| pubmed-article:8837611 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8837611 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:8837611 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8837611 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8837611 | pubmed:pagination | 1122-8 | lld:pubmed |
| pubmed-article:8837611 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8837611 | pubmed:meshHeading | pubmed-meshheading:8837611-... | lld:pubmed |
| pubmed-article:8837611 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8837611 | pubmed:articleTitle | DNA-based immunization by in vivo transfection of dendritic cells. | lld:pubmed |
| pubmed-article:8837611 | pubmed:affiliation | Department of Dermatology, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA. | lld:pubmed |
| pubmed-article:8837611 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8837611 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8837611 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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