Linked Life Data

8829619

Source:http://linkedlifedata.com/resource/pubmed/id/8829619

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-10-17
pubmed:abstractText
Michaelis-Menten constant (Km) and maximum velocity (Vmax) of catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) in various tissues of exercise-trained old rats were compared with the age matched sedentary control. Exercise training increased the maximum velocity (Vmax) for CAT in the brain (350%), liver (33%), lung (34%), muscle (25%) and testes (21%); for GSH-Px (using t-butyl hydroperoxide as a substrate) in the liver (22%), lung (25%), and testes (52%); for GSH-Px (using GSH as a cosubstrate) in the brain (64%) and liver (100%), and for GR in testes (50%). This increase in Vmax indicates the potential activation of these enzymes in the specific tissues. Exercise training differentially altered the affinities of enzyme (Km) for CAT, GSH-Px and GR to their substrates. These studies suggest that exercise training provided a beneficial role by activation of antioxidant enzymes in specific tissues of aged rats. Thus, exercise training aids in coping with oxidative stress in old age.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1039-9712
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
587-95
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Exercise training alters kinetics of antioxidant enzymes in rat tissues.
pubmed:affiliation
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield 62794-1222, USA.
pubmed:publicationType
Journal Article