|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
1996-11-15
|
|
pubmed:abstractText |
Transgenic mice expressing either the neu proto-oncogene or transforming growth factor (TGF-alpha) in the mammary epithelium develop spontaneous focal mammary tumors that occur after a long latency. Since the epidermal growth factor receptor (EGFR) and Neu are capable of forming heterodimers that are responsive to EGFR ligands such as TGF-alpha, we examined whether coexpression of TGF-alpha and Neu in mammary epithelium could cooperate to accelerate the onset of mammary tumors. To test this hypothesis, we interbred separate transgenic strains harboring either a mouse mammary tumor virus/TGF-alpha or a mouse mammary tumor virus/neu transgene to generate bitransgenic mice that coexpress TGF-alpha and neu in the mammary epithelium. Female mice coexpressing TGF-alpha and neu developed multifocal mammary tumors which arose after a significantly shorter latency period than either parental strain alone. The development of these mammary tumors was correlated with the tyrosine phosphorylation of Neu and the recruitment of c-Src to the Neu complex. Immunoprecipitation and immunoblot analyses with EGFR- and Neu-specific antisera, however, failed to detect physical complexes of these two receptors. Taken together, these observations suggest that Neu and TGF-alpha cooperate in mammary tumorigenesis through a mechanism involving Neu and EGFR transactivation.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-1359541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-1670762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-1672253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-1683701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-1693546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-1970151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-1973074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-1980216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-2158859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-2161707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-2164210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-2350785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-2470152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-2567634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-2568888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-2687875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-2871941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-2897079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-2898299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-2899889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-2992089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-3261240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-3299059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-3542714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-3798106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-6091052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-6504162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-7515147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-7533293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-7542762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-7903421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-7907001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-7935422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-8026468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-8125255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8816486-8383326
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0270-7306
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
16
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
5726-36
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:8816486-Aging,
pubmed-meshheading:8816486-Animals,
pubmed-meshheading:8816486-Cell Transformation, Neoplastic,
pubmed-meshheading:8816486-Dimerization,
pubmed-meshheading:8816486-Epithelium,
pubmed-meshheading:8816486-Female,
pubmed-meshheading:8816486-Genes, erbB-2,
pubmed-meshheading:8816486-Mammary Glands, Animal,
pubmed-meshheading:8816486-Mammary Neoplasms, Experimental,
pubmed-meshheading:8816486-Mammary Tumor Virus, Mouse,
pubmed-meshheading:8816486-Mice,
pubmed-meshheading:8816486-Mice, Transgenic,
pubmed-meshheading:8816486-Phosphorylation,
pubmed-meshheading:8816486-Receptor, erbB-2,
pubmed-meshheading:8816486-Transcription, Genetic,
pubmed-meshheading:8816486-Transforming Growth Factor alpha
|
|
pubmed:year |
1996
|
|
pubmed:articleTitle |
Synergistic interaction of the Neu proto-oncogene product and transforming growth factor alpha in the mammary epithelium of transgenic mice.
|
|
pubmed:affiliation |
Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|
