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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
1996-11-21
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pubmed:abstractText |
We report here that 85% of the patients with germ cell tumors (GCTs) produce antibodies directed against Env protein of human endogenous retroviruses. Individuals that received antitumor treatment showed a decrease with time in their antibody titers. Importantly, of the rare cases of non-GCT individuals with Env-antibodies (n= 15, 0.8%), none produced antibodies directed against the transmembrane domain (TM), whereas all tested Env-positive GCT patients (n= 49) generated such antibodies at high titers. TM is required for Env to be expressed at the cell surface. Thus, anti-TM antibodies constitute highly specific markers for GCT and may hint at a function of Env during tumorigenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, env,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, gag,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0008-5472
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4362-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8813125-Animals,
pubmed-meshheading:8813125-Antibodies, Neoplasm,
pubmed-meshheading:8813125-Antibodies, Viral,
pubmed-meshheading:8813125-Antibody Specificity,
pubmed-meshheading:8813125-Antigens, Neoplasm,
pubmed-meshheading:8813125-Cell Line,
pubmed-meshheading:8813125-Female,
pubmed-meshheading:8813125-Gene Products, env,
pubmed-meshheading:8813125-Gene Products, gag,
pubmed-meshheading:8813125-Germinoma,
pubmed-meshheading:8813125-Humans,
pubmed-meshheading:8813125-Male,
pubmed-meshheading:8813125-Neoplasms,
pubmed-meshheading:8813125-Nucleopolyhedrovirus,
pubmed-meshheading:8813125-Peptide Fragments,
pubmed-meshheading:8813125-Recombinant Proteins,
pubmed-meshheading:8813125-Retroviridae,
pubmed-meshheading:8813125-Spodoptera,
pubmed-meshheading:8813125-Testicular Diseases,
pubmed-meshheading:8813125-Testicular Neoplasms,
pubmed-meshheading:8813125-Tumor Markers, Biological
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pubmed:year |
1996
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pubmed:articleTitle |
Specificity of antibodies directed against Env protein of human endogenous retroviruses in patients with germ cell tumors.
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pubmed:affiliation |
Abteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene, Universitätskliniken des Saarlandes, Homburg/Saar, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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