| pubmed-article:8813113 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8813113 | lifeskim:mentions | umls-concept:C0017296 | lld:lifeskim |
| pubmed-article:8813113 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:8813113 | lifeskim:mentions | umls-concept:C0034538 | lld:lifeskim |
| pubmed-article:8813113 | lifeskim:mentions | umls-concept:C1658953 | lld:lifeskim |
| pubmed-article:8813113 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:8813113 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:8813113 | lifeskim:mentions | umls-concept:C1883709 | lld:lifeskim |
| pubmed-article:8813113 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:8813113 | pubmed:dateCreated | 1996-11-21 | lld:pubmed |
| pubmed-article:8813113 | pubmed:abstractText | Intratumoral injection of an adenoviral vector containing radiation-inducible DNA sequences of the Egr-1 promoter linked to a cDNA encoding tumor necrosis factor (TNF) alpha (Ad.Egr-TNF) enhances the tumoricidal action of ionizing radiation in a human epidermoid carcinoma xenograft (SQ-20B). The dominant histopathological feature in tumor-bearing animals treated with Ad.Egr-TNF and irradiation is extensive intratumoral vascular thrombosis and tumor necrosis. Thrombosis and necrosis are not observed in animals treated with either the viral construct encoding TNF-alpha or radiation and did not occur in irradiated normal tissues adjacent to tumor in animals injected with Ad.Egr-TNF. To determine if the occlusive effects of Ad.Egr-TNF and X-irradiation were specific for tumor vessels, non-tumor-bearing mice were irradiated after receiving i.m. injection of Ad.Egr-TNF at viral titers 20-100 times greater than titers injected intratumorally. No vascular thrombosis was observed in the treated normal tissues. Combined Ad.Egr-TNF and radiation produced occlusion of tumor microvessels without significant normal tissue damage. Taken together, these data suggest that the interaction between radiation inducible TNF-alpha and X-irradiation occurs selectively within the tumor vessels. | lld:pubmed |
| pubmed-article:8813113 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8813113 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8813113 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8813113 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8813113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8813113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8813113 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8813113 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8813113 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:8813113 | pubmed:author | pubmed-author:HellmanSS | lld:pubmed |
| pubmed-article:8813113 | pubmed:author | pubmed-author:WeichselbaumR... | lld:pubmed |
| pubmed-article:8813113 | pubmed:author | pubmed-author:HallahanD EDE | lld:pubmed |
| pubmed-article:8813113 | pubmed:author | pubmed-author:WayneJ DJD | lld:pubmed |
| pubmed-article:8813113 | pubmed:author | pubmed-author:MauceriH JHJ | lld:pubmed |
| pubmed-article:8813113 | pubmed:author | pubmed-author:HannaN NNN | lld:pubmed |
| pubmed-article:8813113 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8813113 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8813113 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:8813113 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8813113 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8813113 | pubmed:pagination | 4311-4 | lld:pubmed |
| pubmed-article:8813113 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8813113 | pubmed:meshHeading | pubmed-meshheading:8813113-... | lld:pubmed |
| pubmed-article:8813113 | pubmed:meshHeading | pubmed-meshheading:8813113-... | lld:pubmed |
| pubmed-article:8813113 | pubmed:meshHeading | pubmed-meshheading:8813113-... | lld:pubmed |
| pubmed-article:8813113 | pubmed:meshHeading | pubmed-meshheading:8813113-... | lld:pubmed |
| pubmed-article:8813113 | pubmed:meshHeading | pubmed-meshheading:8813113-... | lld:pubmed |
| pubmed-article:8813113 | pubmed:meshHeading | pubmed-meshheading:8813113-... | lld:pubmed |
| pubmed-article:8813113 | pubmed:meshHeading | pubmed-meshheading:8813113-... | lld:pubmed |
| pubmed-article:8813113 | pubmed:meshHeading | pubmed-meshheading:8813113-... | lld:pubmed |
| pubmed-article:8813113 | pubmed:meshHeading | pubmed-meshheading:8813113-... | lld:pubmed |
| pubmed-article:8813113 | pubmed:meshHeading | pubmed-meshheading:8813113-... | lld:pubmed |
| pubmed-article:8813113 | pubmed:meshHeading | pubmed-meshheading:8813113-... | lld:pubmed |
| pubmed-article:8813113 | pubmed:meshHeading | pubmed-meshheading:8813113-... | lld:pubmed |
| pubmed-article:8813113 | pubmed:meshHeading | pubmed-meshheading:8813113-... | lld:pubmed |
| pubmed-article:8813113 | pubmed:meshHeading | pubmed-meshheading:8813113-... | lld:pubmed |
| pubmed-article:8813113 | pubmed:meshHeading | pubmed-meshheading:8813113-... | lld:pubmed |
| pubmed-article:8813113 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8813113 | pubmed:articleTitle | Tumor necrosis factor alpha (TNF-alpha) gene therapy targeted by ionizing radiation selectively damages tumor vasculature. | lld:pubmed |
| pubmed-article:8813113 | pubmed:affiliation | Department of Radiation and Cellular Oncology, Pritzker School of Medicine, University of Chicago, Illinois 60637, USA. | lld:pubmed |
| pubmed-article:8813113 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8813113 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8813113 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8813113 | lld:pubmed |
