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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2-3
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pubmed:dateCreated |
1996-12-10
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pubmed:abstractText |
Bordetella pertussis produces a catalase and a Fe-superoxide dismutase. The importance of these enzymes in virulence was investigated, in vitro as well as in vivo, by using mutants deficient in their production. The catalase-deficient mutant survived within polymorphonuclear leukocytes, killed J774A.1 macrophages through apoptosis, and behaved as the parental strain in a murine respiratory infection model. These results suggest no direct role for catalase in B. pertussis virulence. The absence of expression of Fe-superoxide dismutase had profound effects on the bacterium including a reduced ability to express adenylate cyclase-hemolysin and pertactin, two factors important for B. pertussis pathogenesis. The Fe-superoxide dismutase-deficient mutant also had decreased abilities to colonize and persist in the murine respiratory infection model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0378-1097
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
142
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
231-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8810507-Adenylate Cyclase Toxin,
pubmed-meshheading:8810507-Animals,
pubmed-meshheading:8810507-Apoptosis,
pubmed-meshheading:8810507-Bacterial Outer Membrane Proteins,
pubmed-meshheading:8810507-Bacterial Proteins,
pubmed-meshheading:8810507-Bordetella Infections,
pubmed-meshheading:8810507-Bordetella pertussis,
pubmed-meshheading:8810507-Catalase,
pubmed-meshheading:8810507-Cells, Cultured,
pubmed-meshheading:8810507-Immunoblotting,
pubmed-meshheading:8810507-Leukocytes, Mononuclear,
pubmed-meshheading:8810507-Macrophages,
pubmed-meshheading:8810507-Mice,
pubmed-meshheading:8810507-Mutagenesis,
pubmed-meshheading:8810507-Mutagenesis, Insertional,
pubmed-meshheading:8810507-Paraquat,
pubmed-meshheading:8810507-Protein Precursors,
pubmed-meshheading:8810507-Superoxide Dismutase,
pubmed-meshheading:8810507-Virulence,
pubmed-meshheading:8810507-Virulence Factors, Bordetella
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pubmed:year |
1996
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pubmed:articleTitle |
In vivo and in vitro analysis of Bordetella pertussis catalase and Fe-superoxide dismutase mutants.
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pubmed:affiliation |
Laboratoire des Bordetella, Institut Pasteur, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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