Linked Life Data

8806621

Source:http://linkedlifedata.com/resource/pubmed/id/8806621

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1996-10-22
pubmed:abstractText
Sst2 formally acts as an inhibitor of G protein-coupled receptor signaling in yeast perhaps stabilizing a G protein/unactivated receptor complex. desTrp1,Ala3 alpha-factor (dTA-alpha f), normally a competitive antagonist, activated responses in an sst2 strain. The antagonist to agonist switch was consistent with an Sst2 effect on receptor/G protein coupling, but not with an Sst2 role in global reduction of signaling. Response to alpha-factor, assayed by growth arrest, was independent of level of expressed surface receptor over a 40-fold range in an SST2+ strain, consistent with coupling of only a subset of receptors to G protein. In contrast, in an sst2 strain response to alpha-factor was proportional to receptor expression, consistent with participation of all receptors in signaling. The wt alpha-factor receptor inhibited signaling in response to dTA-alpha f when introduced into a CKC4 chimeric receptor strain. The dominant-negative effect of the receptor might reflect sequestration of G protein.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
226
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
242-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Role of Sst2 in modulating G protein-coupled receptor signaling.
pubmed:affiliation
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't