Source:http://linkedlifedata.com/resource/umls/id/C1517377
NCI: A cellular process that initiates with the binding of a G protein-associated transmembrane receptor to its cognate ligand,and results in a specific cellular response. This process is involved in signaling related to neurotranmission, immune responses, and cellular metabolism, differentiation and proliferation.,NCI: G Protein-Coupled Receptor (GPCR) Signaling involves interactions of agonists with seven membrane-spanning receptors that induce receptor interaction with a heterotrimeric GTP-binding (G) protein complex, activation of GDP-GTP exchange on the G protein Ga subunit, dissociation of Ga from the Gbg heterodimer, and interaction of the subunits with intracellular effectors causing signal transduction cascades. GPCRs are coupled to different G protein subtypes that can activate or inhibit adenylyl cyclase, ion channels, PLC, PKC, CaM-KII, MAPKs, Src kinases, PI(3)K, Pyk2 and/or FAK in such diverse processes as neurotransmission, cellular metabolism, cell differentiation, cell proliferation, and immu