Linked Life Data

8805763

Source:http://linkedlifedata.com/resource/pubmed/id/8805763

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-11-6
pubmed:abstractText
Olson (1993, Annals of Human Genetics 57, 291-295) proposed a large-sample test of Hardy-Weinberg equilibrium when genotype data are sampled from several populations with different allele frequencies. The test assumes that a ratio measure of disequilibrium is constant across the populations. In this paper, we consider the problem of testing the assumption of homogeneity of that ratio and propose both a large-sample test and an exact test. The large-sample test is appropriate if sample sizes in all strata are sufficiently large, but is strongly anticonservative if some strata are small. In the latter case, the exact test is preferred and we approximate the P-value of this test using a Markov chain Monte Carlo approach.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0006-341X
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
971-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Testing for homogeneity of Hardy-Weinberg disequilibrium using data sampled from several populations.
pubmed:affiliation
Department of Epidemiology and Biostatistics, Case Western Reserve University, MetroHealth Medical Center R258, Cleveland, Ohio 44109-1998, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.