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rdf:type |
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lifeskim:mentions |
umls-concept:C0018296,
umls-concept:C0086418,
umls-concept:C0208973,
umls-concept:C0752312,
umls-concept:C1150587,
umls-concept:C1334043,
umls-concept:C1367731,
umls-concept:C1420476,
umls-concept:C1517892,
umls-concept:C1704259,
umls-concept:C1704666,
umls-concept:C1705632,
umls-concept:C1705987
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pubmed:issue |
5
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pubmed:dateCreated |
1997-3-10
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pubmed:databankReference |
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pubmed:abstractText |
The Rho-related GTP-binding proteins Cdc42 and Rac1 have been shown to regulate signaling pathways involved in cytoskeletal reorganization and stress-responsive JNK (Jun N-terminal kinase) activation. However, to date, the GTPase targets that mediate these effects have not been identified. PAK defines a growing family of mammalian kinases that are related to yeast Ste20 and are activated in vitro through binding to Cdc42 and Rac1 (PAK: p21 Cdc42-/Rac-activated kinase). Clues to PAK function have come from studies of Ste20, which controls the activity of the yeast mating mitogen-activated protein (MAP) kinase cascade, in response to a heterotrimeric G protein and Cdc42.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/GTP Phosphohydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/PAK1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/PRK1 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/cdc42 GTP-Binding Protein,
http://linkedlifedata.com/resource/pubmed/chemical/p21-Activated Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-9822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
598-605
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pubmed:dateRevised |
2010-3-24
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pubmed:meshHeading |
pubmed-meshheading:8805275-Alleles,
pubmed-meshheading:8805275-Amino Acid Sequence,
pubmed-meshheading:8805275-Base Sequence,
pubmed-meshheading:8805275-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:8805275-Cell Cycle Proteins,
pubmed-meshheading:8805275-Cloning, Molecular,
pubmed-meshheading:8805275-DNA, Complementary,
pubmed-meshheading:8805275-Enzyme Activation,
pubmed-meshheading:8805275-GTP Phosphohydrolases,
pubmed-meshheading:8805275-GTP-Binding Proteins,
pubmed-meshheading:8805275-Humans,
pubmed-meshheading:8805275-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:8805275-Mitogen-Activated Protein Kinases,
pubmed-meshheading:8805275-Molecular Sequence Data,
pubmed-meshheading:8805275-Mutagenesis,
pubmed-meshheading:8805275-Protein-Serine-Threonine Kinases,
pubmed-meshheading:8805275-Saccharomyces cerevisiae,
pubmed-meshheading:8805275-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:8805275-Signal Transduction,
pubmed-meshheading:8805275-cdc42 GTP-Binding Protein,
pubmed-meshheading:8805275-p21-Activated Kinases
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pubmed:year |
1996
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pubmed:articleTitle |
Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway.
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pubmed:affiliation |
Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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