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rdf:type |
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lifeskim:mentions |
umls-concept:C0013138,
umls-concept:C0017262,
umls-concept:C0017347,
umls-concept:C0018787,
umls-concept:C0042567,
umls-concept:C0086282,
umls-concept:C0185117,
umls-concept:C0205314,
umls-concept:C0443199,
umls-concept:C0679622,
umls-concept:C0680022,
umls-concept:C1334043,
umls-concept:C1656559,
umls-concept:C1882932,
umls-concept:C2911684
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pubmed:issue |
1-2
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|
pubmed:dateCreated |
1997-2-5
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pubmed:databankReference |
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pubmed:abstractText |
NKx homeodomain proteins are members of a growing family of vertebrate transcription factors with strong homology to the NK genes in Drosophila. Here, we describe the cloning of cNKx-2.3 and cNKx-2.5 cDNAs and their expression during chick development. Both genes are expressed in the developing heart with distinct but overlapping spatio-temporal patterns. While cNKx-2.5 is activated in early precardiac mesoderm and continues to be uniformly expressed throughout the mature heart, expression of NKx-2.3 starts later in differentiated myocardial cells with regional differences compared to NKx-2.5. Additionally, both genes are expressed in adjacent domains of the developing mid- and hindgut mesoderm as well as in branchial arches. The highly conserved structure of cNKx-2.5 and its similar expression to mouse and Xenopus NKx-2.5 genes and to the Drosophila gene tinman argue that it constitutes the chick homologue of these genes. Different temporal and spatial activity of cNKx-2.3 in heart and gut as well as in a regionally restricted expression domain in the neural tube suggest that cNKx-2.3 is a member of the NK-2 gene family which may be involved in specifying mesodermally and ectodermally derived cell types in the embryo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0925-4773
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
151-63
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8798155-Animals,
pubmed-meshheading:8798155-Avian Proteins,
pubmed-meshheading:8798155-Base Sequence,
pubmed-meshheading:8798155-Chick Embryo,
pubmed-meshheading:8798155-Chickens,
pubmed-meshheading:8798155-Drosophila melanogaster,
pubmed-meshheading:8798155-Gene Expression Regulation, Developmental,
pubmed-meshheading:8798155-Genes, Homeobox,
pubmed-meshheading:8798155-Heart,
pubmed-meshheading:8798155-Homeodomain Proteins,
pubmed-meshheading:8798155-Intestines,
pubmed-meshheading:8798155-Mesoderm,
pubmed-meshheading:8798155-Mice,
pubmed-meshheading:8798155-Molecular Sequence Data,
pubmed-meshheading:8798155-Morphogenesis,
pubmed-meshheading:8798155-Myocardium,
pubmed-meshheading:8798155-Organ Specificity,
pubmed-meshheading:8798155-Sequence Alignment,
pubmed-meshheading:8798155-Sequence Homology,
pubmed-meshheading:8798155-Sequence Homology, Amino Acid,
pubmed-meshheading:8798155-Species Specificity,
pubmed-meshheading:8798155-Transcription Factors,
pubmed-meshheading:8798155-Xenopus Proteins,
pubmed-meshheading:8798155-Xenopus laevis
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pubmed:year |
1996
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pubmed:articleTitle |
Chick NKx-2.3 represents a novel family member of vertebrate homologues to the Drosophila homeobox gene tinman: differential expression of cNKx-2.3 and cNKx-2.5 during heart and gut development.
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pubmed:affiliation |
Department of Cell and Molecular Biology, University of Braunschweig, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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