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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1996-12-16
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pubmed:abstractText |
Invertebrate photoreceptors use the ubiquitous inositol-lipid signaling pathway for phototransduction. This pathway depends on Ca2+ release from internal stores and on Ca2+ entry via light-activated channels to replenish the loss of Ca2+ in those stores. The Drosophila transient receptor potential (TRP) protein is essential for the high Ca2+ permeability and other biophysical properties of these light-activated channels, which affect both excitation and adaptation in photoreceptor cells. Physiological and heterologous expression studies indicate that TRP is a putative subunit of a surface membrane channel that can be activated by depletion of internal Ca2+ stores. Furthermore, trp is an archetypal member of a multigene family whose products share a structure that is highly conserved throughout evolution, from worms to humans.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0959-4388
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
459-66
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8794093-Adaptation, Ocular,
pubmed-meshheading:8794093-Animals,
pubmed-meshheading:8794093-Biological Evolution,
pubmed-meshheading:8794093-Calcium,
pubmed-meshheading:8794093-Calcium Channels,
pubmed-meshheading:8794093-Cations, Divalent,
pubmed-meshheading:8794093-Conserved Sequence,
pubmed-meshheading:8794093-Drosophila,
pubmed-meshheading:8794093-Ion Channels,
pubmed-meshheading:8794093-Light,
pubmed-meshheading:8794093-Mutation,
pubmed-meshheading:8794093-Permeability,
pubmed-meshheading:8794093-Photoreceptor Cells, Invertebrate,
pubmed-meshheading:8794093-TRPC Cation Channels
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pubmed:year |
1996
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pubmed:articleTitle |
The roles of trp and calcium in regulating photoreceptor function in Drosophila.
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pubmed:affiliation |
Department of Physiology, The Hebrew University - Hadassah Medical School, Jerusalem 91120, Israel. minke@md2.huji.ac.il
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review,
Research Support, Non-U.S. Gov't
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