Linked Life Data

8779877

Source:http://linkedlifedata.com/resource/pubmed/id/8779877

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2 Pt 2
pubmed:dateCreated
1996-12-20
pubmed:abstractText
To determine whether endogenous lateral hypothalamic (LH) glutamate and its N-methyl-D-aspartate (NMDA) receptors might participate in the stimulation of natural eating, LH injection of the NMDA antagonist D-(-)-2-amino-5-phosphonopentanoic acid (D-AP5) was tested in adult male rats for suppressive actions on feeding elicited by 1) NMDA, kainic acid or D, L-alpha-amino-3-hydroxy-5-methylisoxazole (AMPA) injected into the LH; 2) food deprivation; and 3) the onset of the nocturnal period. D-AP5 (10-100 nmol) reduced by 72-90% the approximately 10-g eating response elicited by NMDA (10 nmol) without affecting the quantitatively similar eating responses elicited by kainic acid (1.0 nmol) or AMPA (1.0 nmol). This treatment also suppressed deprivation-induced eating by as much as 61% and nocturnal eating by as much as 40%. To determine its long-term effects, D-AP5 (50 nmol) was injected bilaterally into the LH twice a day for 8 consecutive days. This treatment caused up to 65% reductions in daily food intake and body weight loss of up to 13 g/day. These findings, showing behaviorally selective suppressions of eating and body weight by D-AP5, argue that endogenous LH glutamate acts to regulate natural eating and body weight and that NMDA receptors participate in these functions.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
270
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R443-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:8779877-2-Amino-5-phosphonovalerate, pubmed-meshheading:8779877-Animals, pubmed-meshheading:8779877-Body Weight, pubmed-meshheading:8779877-Circadian Rhythm, pubmed-meshheading:8779877-Eating, pubmed-meshheading:8779877-Excitatory Amino Acid Antagonists, pubmed-meshheading:8779877-Food Deprivation, pubmed-meshheading:8779877-Glutamic Acid, pubmed-meshheading:8779877-Hypothalamic Area, Lateral, pubmed-meshheading:8779877-Kainic Acid, pubmed-meshheading:8779877-Male, pubmed-meshheading:8779877-N-Methylaspartate, pubmed-meshheading:8779877-Rats, pubmed-meshheading:8779877-Rats, Sprague-Dawley, pubmed-meshheading:8779877-Receptors, N-Methyl-D-Aspartate, pubmed-meshheading:8779877-Time Factors, pubmed-meshheading:8779877-alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
pubmed:year
1996
pubmed:articleTitle
Lateral hypothalamic NMDA receptors and glutamate as physiological mediators of eating and weight control.
pubmed:affiliation
Department of Neuroscience, University of California, Riverside 92521, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't