Linked Life Data

8770654

Source:http://linkedlifedata.com/resource/pubmed/id/8770654

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1996-10-9
pubmed:abstractText
It has been proposed that neurodegenerative processes of aging are associated with the generation of reactive oxygen species (ROS) during cellular metabolism. These reactive oxygen species are scavenged by antioxidant enzymes in biological systems. The present study was designed to determine the selective distribution of the antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase activity and reduced glutathione (GSH) levels in different regions of the C57BL/6N mouse brain and to determine if any alterations occurred with age. Catalase activity did not show any significant change except in cerebellum. Activity of superoxide dismutase was increased with age in all regions of the brain except in hippocampus of 2-yr-old mice. The glutathione peroxidase activity in the caudate nucleus increased in all regions of the brain, however, the activity did not change at one, six and 12 months. A significant increasing pattern of glutathione content was found in the cerebellum and brain stem with age. These data demonstrate that although the level of antioxidant enzymes varied in different regions of the brain, overall the enzyme activities tend to increase with age.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0736-5748
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
811-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Age-related changes in antioxidant enzymes, superoxide dismutase, catalase, glutathione peroxidase and glutathione in different regions of mouse brain.
pubmed:affiliation
Neurochemistry Laboratory, National Center for Toxicological Research/FDA, Jefferson, AR 72079, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.