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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
1996-9-20
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pubmed:abstractText |
Herein we show that exposure of human umbilical vein endothelial cells to tumor necrosis factor alpha (TNFalpha) led to platelet endothelial cell adhesion molecule-1 (PECAM1) surface redistribution, disruption of cytoskeleton connections, and increased PECAM1 phosphorylation, accompanied by increased permeability to macromolecules. The in vitro use of inhibitors of tyrosine or serine-threonine kinases could prevent both PECAM1 surface redistribution and the increase in permeability induced by the cytokine. In vivo administration of lavendustin A, a natural tyrosine kinase inhibitor, protected endothelial cells from TNFalpha-dependent vascular leakage in mouse liver. We propose that the involvement of PECAM1 in TNFalpha-mediated effects on vascular permeability may depend on a dynamically regulated cytoskeletal association, related to the degree of PECAM1 phosphorylation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaloids,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD31,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Benzoquinones,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Lactams, Macrocyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Quinones,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Staurosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/herbimycin
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0008-5472
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3211-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8764109-Alkaloids,
pubmed-meshheading:8764109-Antigens, CD31,
pubmed-meshheading:8764109-Antigens, Differentiation, Myelomonocytic,
pubmed-meshheading:8764109-Benzoquinones,
pubmed-meshheading:8764109-Capillary Permeability,
pubmed-meshheading:8764109-Cell Adhesion Molecules,
pubmed-meshheading:8764109-Cell Compartmentation,
pubmed-meshheading:8764109-Cells, Cultured,
pubmed-meshheading:8764109-Endothelium, Vascular,
pubmed-meshheading:8764109-Enzyme Inhibitors,
pubmed-meshheading:8764109-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:8764109-Gene Expression,
pubmed-meshheading:8764109-Humans,
pubmed-meshheading:8764109-Lactams, Macrocyclic,
pubmed-meshheading:8764109-Phosphorylation,
pubmed-meshheading:8764109-Protein Kinase Inhibitors,
pubmed-meshheading:8764109-Quinones,
pubmed-meshheading:8764109-RNA, Messenger,
pubmed-meshheading:8764109-Staurosporine,
pubmed-meshheading:8764109-Tumor Necrosis Factor-alpha,
pubmed-meshheading:8764109-Umbilical Veins
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pubmed:year |
1996
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pubmed:articleTitle |
Tumor necrosis factor alpha-induced vascular leakage involves PECAM1 phosphorylation.
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pubmed:affiliation |
Laboratory of Tumor Immunology, Scientific Institute San Raffaele, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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