| pubmed-article:8760828 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8760828 | lifeskim:mentions | umls-concept:C0017349 | lld:lifeskim |
| pubmed-article:8760828 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:8760828 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:8760828 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:8760828 | lifeskim:mentions | umls-concept:C0054959 | lld:lifeskim |
| pubmed-article:8760828 | lifeskim:mentions | umls-concept:C0013081 | lld:lifeskim |
| pubmed-article:8760828 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:8760828 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:8760828 | lifeskim:mentions | umls-concept:C1819439 | lld:lifeskim |
| pubmed-article:8760828 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:8760828 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8760828 | pubmed:dateCreated | 1996-9-23 | lld:pubmed |
| pubmed-article:8760828 | pubmed:abstractText | We have shown previously that dendritic cells (DC) produce IL-12 upon interaction with CD4+ T cells. Here we ask how this IL-12 production is induced and regulated. Quantitative PCR and in situ hybridization for IL-12 p40 and an ELISA specific for the p70 heterodimer were used to determine IL-12 production. We demonstrate that ligation of either CD40 or MHC class II molecules independently trigger IL-12 production in DC, and that IL-12 production is downregulated by IL-4 and IL-10. The levels of bioactive IL-12 that can be released by triggering with an anti-CD40 mAb or with a T cell hybridoma are high (range 260-4700 pg/ml from 1 X 10(6) DC in 72 h). The CD40-mediated pathway indicates that IL-12 production is induced in DC upon interaction with activated, CD40 ligand-expressing helper T cells, even in the absence of cognate antigen recognition. Side-by-side comparison of IL-12 production, and blocking experiments employing an anti-CD40 ligand mAb, suggest that the CD40-mediated pathway is quantitatively more significant than induction via the MHC class II molecule. The importance of the CD40/CD40 ligand interaction for IL-12 induction in DC likely contributes to the recent finding that mice lacking the CD40 ligand are impaired in mounting Th1 type cell-mediated immune responses. | lld:pubmed |
| pubmed-article:8760828 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8760828 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8760828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760828 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8760828 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8760828 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:8760828 | pubmed:author | pubmed-author:KochFF | lld:pubmed |
| pubmed-article:8760828 | pubmed:author | pubmed-author:RomanoPP | lld:pubmed |
| pubmed-article:8760828 | pubmed:author | pubmed-author:SchulerGG | lld:pubmed |
| pubmed-article:8760828 | pubmed:author | pubmed-author:JenneweinPP | lld:pubmed |
| pubmed-article:8760828 | pubmed:author | pubmed-author:HeuflerCC | lld:pubmed |
| pubmed-article:8760828 | pubmed:author | pubmed-author:KämpgenEE | lld:pubmed |
| pubmed-article:8760828 | pubmed:author | pubmed-author:StanzlUU | lld:pubmed |
| pubmed-article:8760828 | pubmed:author | pubmed-author:JankeKK | lld:pubmed |
| pubmed-article:8760828 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8760828 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8760828 | pubmed:volume | 184 | lld:pubmed |
| pubmed-article:8760828 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8760828 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8760828 | pubmed:pagination | 741-6 | lld:pubmed |
| pubmed-article:8760828 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:8760828 | pubmed:meshHeading | pubmed-meshheading:8760828-... | lld:pubmed |
| pubmed-article:8760828 | pubmed:meshHeading | pubmed-meshheading:8760828-... | lld:pubmed |
| pubmed-article:8760828 | pubmed:meshHeading | pubmed-meshheading:8760828-... | lld:pubmed |
| pubmed-article:8760828 | pubmed:meshHeading | pubmed-meshheading:8760828-... | lld:pubmed |
| pubmed-article:8760828 | pubmed:meshHeading | pubmed-meshheading:8760828-... | lld:pubmed |
| pubmed-article:8760828 | pubmed:meshHeading | pubmed-meshheading:8760828-... | lld:pubmed |
| pubmed-article:8760828 | pubmed:meshHeading | pubmed-meshheading:8760828-... | lld:pubmed |
| pubmed-article:8760828 | pubmed:meshHeading | pubmed-meshheading:8760828-... | lld:pubmed |
| pubmed-article:8760828 | pubmed:meshHeading | pubmed-meshheading:8760828-... | lld:pubmed |
| pubmed-article:8760828 | pubmed:meshHeading | pubmed-meshheading:8760828-... | lld:pubmed |
| pubmed-article:8760828 | pubmed:meshHeading | pubmed-meshheading:8760828-... | lld:pubmed |
| pubmed-article:8760828 | pubmed:meshHeading | pubmed-meshheading:8760828-... | lld:pubmed |
| pubmed-article:8760828 | pubmed:meshHeading | pubmed-meshheading:8760828-... | lld:pubmed |
| pubmed-article:8760828 | pubmed:meshHeading | pubmed-meshheading:8760828-... | lld:pubmed |
| pubmed-article:8760828 | pubmed:meshHeading | pubmed-meshheading:8760828-... | lld:pubmed |
| pubmed-article:8760828 | pubmed:meshHeading | pubmed-meshheading:8760828-... | lld:pubmed |
| pubmed-article:8760828 | pubmed:meshHeading | pubmed-meshheading:8760828-... | lld:pubmed |
| pubmed-article:8760828 | pubmed:meshHeading | pubmed-meshheading:8760828-... | lld:pubmed |
| pubmed-article:8760828 | pubmed:meshHeading | pubmed-meshheading:8760828-... | lld:pubmed |
| pubmed-article:8760828 | pubmed:meshHeading | pubmed-meshheading:8760828-... | lld:pubmed |
| pubmed-article:8760828 | pubmed:meshHeading | pubmed-meshheading:8760828-... | lld:pubmed |
| pubmed-article:8760828 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8760828 | pubmed:articleTitle | High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. | lld:pubmed |
| pubmed-article:8760828 | pubmed:affiliation | Department of Dermatology, University of Innsbruck, Austria. | lld:pubmed |
| pubmed-article:8760828 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8760828 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8760828 | lld:pubmed |
